Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics (Q44447688)

3 December 2017

Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics (English)

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3 December 2017

Rosmarie Friemann

8

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Per-Åke Nygren

object named as

Per-Åke Nygren

11

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Hannes Uchtenhagen

3

object named as

Hannes Uchtenhagen

1 reference

3 December 2017

10

Tatyana Sandalova

1 reference

3 December 2017

Eva B Allerbring

1

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3 December 2017

Adil D Duru

2

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3 December 2017

Chaithanya Madhurantakam

4

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3 December 2017

Markus B Tomek

5

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3 December 2017

Sebastian Grimm

6

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3 December 2017

Pooja A Mazumdar

7

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3 December 2017

Michael Uhlin

9

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3 December 2017

Adnane Achour

12

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3 December 2017

language of work or name

English

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publication date

20 September 2012

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European Journal of Immunology

3 December 2017

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3 December 2017

42

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3 December 2017

11

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3 December 2017

2990-3000

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The fidelity, occasional promiscuity, and versatility of T cell receptor recognition

3 December 2017

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes

21 January 2018

1 reference

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TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

How a single T cell receptor recognizes both self and foreign MHC

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?

21 January 2018

1 reference

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T cell allorecognition via molecular mimicry

21 January 2018

1 reference

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Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Different Thermodynamic Binding Mechanisms and Peptide Fine Specificities Associated with a Panel of Structurally Similar High-Affinity T Cell Receptors † ‡

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Identification of a crucial energetic footprint on the alpha1 helix of human histocompatibility leukocyte antigen (HLA)-A2 that provides functional interactions for recognition by tax peptide/HLA-A2-specific T cell receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Strategic mutations in the class I major histocompatibility complex HLA-A2 independently affect both peptide binding and T cell receptor recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Unraveling a hotspot for TCR recognition on HLA-A2: evidence against the existence of peptide-independent TCR binding determinants

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Single MHC Mutation Eliminates Enthalpy Associated with T Cell Receptor Binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

How TCRs bind MHCs, peptides, and coreceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Thermodynamics of T-cell receptor-peptide/MHC interactions: progress and opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor

21 January 2018

1 reference

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Allelic polymorphism in the T cell receptor and its impact on immune responses

21 January 2018

1 reference

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T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Potent T cell agonism mediated by a very rapid TCR/pMHC interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

The impact of TCR-binding properties and antigen presentation format on T cell responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanning

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

T cell cross-reactivity and conformational changes during TCR engagement

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

T Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular Flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Viral escape at the molecular level explained by quantitative T-cell receptor/peptide/MHC interactions and the crystal structure of a peptide/MHC complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Peptidic termini play a significant role in TCR recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Design of agonistic altered peptides for the robust induction of CTL directed towards H-2Db in complex with the melanoma-associated epitope gp100

21 January 2018

1 reference

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Structural and kinetic basis for heightened immunogenicity of T cell vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Improved human T-cell responses against synthetic HLA-0201 analog peptides derived from the WT1 oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

T cell receptor antagonist peptides induce positive selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Differences in peptide presentation between B27 subtypes: the importance of the P1 side chain in maintaining high affinity peptide binding to B*2703.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Disparate Degrees of Hypervariable Loop Flexibility Control T-Cell Receptor Cross-Reactivity, Specificity, and Binding Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Crystal structure of a T cell receptor bound to an allogeneic MHC molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Expression, refolding and crystallization of murine MHC class I H-2Db in complex with human beta2-microglobulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

A structural basis for CD8+ T cell-dependent recognition of non-homologous peptide ligands: implications for molecular mimicry in autoreactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Scaling and assessment of data quality

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Phasercrystallographic software

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Refinement of macromolecular structures by the maximum-likelihood method

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Features and development of Coot

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Structural Basis of the Differential Stability and Receptor Specificity of H-2Db in Complex with Murine versus Human β2-Microglobulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Murine class I major histocompatibility complex H–2Dd: expression, refolding and crystallization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

Characterizing the functionality of recombinant T-cell receptors in vitro: a pMHC tetramer based approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

7 January 2021

Two different T cell receptors use different thermodynamic strategies to recognize the same peptide/MHC ligand

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

7 January 2021

TCR binding to peptide-MHC stabilizes a flexible recognition interface

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

7 January 2021

Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

7 January 2021

Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

7 January 2021

A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

7 January 2021

TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

7 January 2021

High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

7 January 2021

Distinct molecular mechanisms account for the specificity of two different T-cell receptors

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242588

7 January 2021

Identifiers

DOI

10.1002/EJI.201242588

1 reference

3 December 2017

1 reference