The impact of TCR-binding properties and antigen presentation format on T cell responsiveness (Q33737674)

29 July 2017

title

The impact of TCR-binding properties and antigen presentation format on T cell responsiveness (English)

1 reference

29 July 2017

Adam S Chervin

1

1 reference

29 July 2017

Jennifer D Stone

2

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29 July 2017

Phillip D Holler

3

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29 July 2017

Ailin Bai

4

1 reference

29 July 2017

Jianzhu Chen

5

1 reference

29 July 2017

Herman N Eisen

6

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29 July 2017

David M Kranz

7

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29 July 2017

language of work or name

English

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publication date

24 June 2009

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29 July 2017

published in

Journal of Immunology

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29 July 2017

volume

183

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29 July 2017

issue

2

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29 July 2017

page(s)

1166-1178

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Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation

29 July 2017

cites work

1 reference

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Variability and robustness in T cell activation from regulated heterogeneity in protein levels

21 June 2018

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Increased mobility of major histocompatibility complex I-peptide complexes decreases the sensitivity of antigen recognition

21 June 2018

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Vaccine adjuvants alter TCR-based selection thresholds.

21 June 2018

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Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity

21 June 2018

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Doubting the TCR coreceptor function of CD8alphaalpha

21 June 2018

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T-cell activation through immunological synapses and kinapses

21 June 2018

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The expansion and maintenance of antigen-selected CD8(+) T cell clones

21 June 2018

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CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions

21 June 2018

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Induced sensitization of tumor stroma leads to eradication of established cancer by T cells

21 June 2018

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Cellular uptake followed by class I MHC presentation of some exogenous peptides contributes to T cell stimulatory capacity

21 June 2018

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Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

21 June 2018

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Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes

21 June 2018

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Cancer regression in patients after transfer of genetically engineered lymphocytes

21 June 2018

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Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality

21 June 2018

1 reference

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Engineering and characterization of a stabilized alpha1/alpha2 module of the class I major histocompatibility complex product Ld.

21 June 2018

1 reference

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How TCRs bind MHCs, peptides, and coreceptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Recognition of fresh human tumor by human peripheral blood lymphocytes transduced with a bicistronic retroviral vector encoding a murine anti-p53 TCR.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Modeling T cell antigen discrimination based on feedback control of digital ERK responses

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes

21 June 2018

1 reference

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Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

How T cells 'see' antigen

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Affinity maturation of secreted IgM pentamers on B cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Molecular interactions mediating T cell antigen recognition

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

TCRs with high affinity for foreign pMHC show self-reactivity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules

21 June 2018

1 reference

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T-cell activation by soluble MHC oligomers can be described by a two-parameter binding model

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Differences in antigen recognition and cytolytic activity of CD8(+) and CD8(-) T cells that express the same antigen-specific receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

In vitro evolution of a T cell receptor with high affinity for peptide/MHC.

21 June 2018

1 reference

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Role of 2CT cell receptor residues in the binding of self- and allo-major histocompatibility complexes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

A kinetic basis for T cell receptor repertoire selection during an immune response

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Antigen-specific T-cell receptors and their reactions with complexes formed by peptides with major histocompatibility complex proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Altered T cell receptor ligands trigger a subset of early T cell signals

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

The law of mass action governs antigen-stimulated cytolytic activity of CD8+ cytotoxic T lymphocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Kinetic proofreading in T-cell receptor signal transduction

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

The influence of epitope density on the estimation of the affinity of antibody for complex antigens

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

T cell killing does not require the formation of a stable mature immunological synapse.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Decreased Binding of Peptides-MHC Class I (pMHC) Multimeric Complexes to CD8 Affects Their Binding Avidity for the TCR But Does Not Significantly Impact on pMHC/TCR Dissociation Rate

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Two-step binding mechanism for T-cell receptor recognition of peptide MHC.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Ligand recognition by alpha beta T cell receptors

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

T cell activation by purified, soluble, class I MHC molecules. Requirement for polyvalency.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Derivation of a T cell hybridoma variant deprived of functional T cell receptor α and β chain transcripts reveals a nonfunctional α-mRNA of BW5147 origin

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841305

Full Activation of the T Cell Receptor Requires Both Clustering and Conformational Changes at CD3

10 December 2018

1 reference

12 December 2020

CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate

1 reference

12 December 2020

The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model

1 reference

12 December 2020

Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

1 reference

12 December 2020

TCR triggering: co-receptor-dependent or -independent?

1 reference

12 December 2020

The interaction of hapten-coupled bacteriophage phi-X-174 with antihapten antibody

1 reference

12 December 2020

Effect of antibody affinity on the isotherm of antibody binding to surface-immobilized antigen

1 reference

12 December 2020

Cooperativity in the antibody binding to surface-adsorbed antigen

1 reference

12 December 2020

Naturally occurring low affinity peptide/MHC class I ligands can mediate negative selection and T cell activation

1 reference

12 December 2020

Alanine scanning mutagenesis of an alphabeta T cell receptor: mapping the energy of antigen recognition

1 reference

12 December 2020

CD8 Expression Allows T Cell Signaling by Monomeric Peptide-MHC Complexes

1 reference

12 December 2020

High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling

1 reference

12 December 2020

T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics

1 reference

12 December 2020

Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties

1 reference

12 December 2020

Cooperation of Human Tumor-Reactive CD4+ and CD8+ T Cells after Redirection of Their Specificity by a High-Affinity p53A2.1-Specific TCR

1 reference

12 December 2020

CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.0900054

1 reference

29 July 2017

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29 July 2017

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