The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells (Q44539646)

4 December 2017

The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells (English)

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4 December 2017

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6

Craig B Thompson

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4 December 2017

Thomas R Johnson

1

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4 December 2017

Kimberley Stone

2

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4 December 2017

Malti Nikrad

3

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4 December 2017

Tammie Yeh

4

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4 December 2017

Wei-Xing Zong

5

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4 December 2017

Alexandre Nesterov

7

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4 December 2017

Andrew S Kraft

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4 December 2017

language of work or name

English

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publication date

1 August 2003

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4 December 2017

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22

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32

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4 December 2017

4953-4963

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1206656

4 December 2017

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Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

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Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis

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An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis

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Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

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Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL

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Molecular sequelae of proteasome inhibition in human multiple myeloma cells

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Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis

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Activation of caspase-3 alone is insufficient for apoptotic morphological changes in human neuroblastoma cells

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Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.

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Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD)

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Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells

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Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition

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7 January 2021

Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia

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7 January 2021

Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression.

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7 January 2021

Differential requirement for caspase 9 in apoptotic pathways in vivo.

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7 January 2021

Apo2L/TRAIL differentially modulates the apoptotic effects of sulindac and a COX-2 selective non-steroidal anti-inflammatory agent in Bax-deficient cells

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7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications

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TRAIL (APO-2L) induces apoptosis in human prostate cancer cells that is inhibitable by Bcl-2.

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7 January 2021

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

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7 January 2021

Bcl-2 oncoprotein protects the human prostatic carcinoma cell line PC3 from TRAIL-mediated apoptosis.

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7 January 2021

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

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7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206656

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4 December 2017

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