Role of protein kinase C and the Sp1-p53 complex in activation of p21(WAF-1) expression by 12-O-tetradecanoylphorbol-13-acetate in human T cells (Q44549000)

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scientific article published in August 2003

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English	Role of protein kinase C and the Sp1-p53 complex in activation of p21(WAF-1) expression by 12-O-tetradecanoylphorbol-13-acetate in human T cells	scientific article published in August 2003

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scholarly article

1 reference

Europe PubMed Central

4 December 2017

Role of protein kinase C and the Sp1-p53 complex in activation of p21(WAF-1) expression by 12-O-tetradecanoylphorbol-13-acetate in human T cells (English)

1 reference

Europe PubMed Central

4 December 2017

Mordechai Aboud

3

object named as

Mordechai Aboud

1 reference

Europe PubMed Central

4 December 2017

Yana Schavinsky-Khrapunsky

1

object named as

Yana Schavinsky-Khrapunsky

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Europe PubMed Central

4 December 2017

author name string

Mahmoud Huleihel

2

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Europe PubMed Central

4 December 2017

Amram Torgeman

4

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Europe PubMed Central

4 December 2017

language of work or name

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publication date

1 August 2003

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Europe PubMed Central

4 December 2017

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Europe PubMed Central

4 December 2017

22

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Europe PubMed Central

4 December 2017

5315-5324

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Europe PubMed Central

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34

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Europe PubMed Central

4 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1206782

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Transcriptional activation of the p21(WAF1,CIP1,SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells

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The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cells

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Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines

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Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter

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Overexpression of p21(waf1) in human T-cell lymphotropic virus type 1-infected cells and its association with cyclin A/cdk2.

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WAF1, a potential mediator of p53 tumor suppression

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Cleavage of CDK inhibitor p21(Cip1/Waf1) by caspases is an early event during DNA damage-induced apoptosis.

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Protective role of p21(Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells

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p53-dependent elevation of p21Waf1 expression by UV light is mediated through mRNA stabilization and involves a vanadate-sensitive regulatory system

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p53 and Sp1 interact and cooperate in the tumor necrosis factor-induced transcriptional activation of the HIV-1 long terminal repeat

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A proliferative p53-responsive element mediates tumor necrosis factor alpha induction of the human immunodeficiency virus type 1 long terminal repeat

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Inhibition of cyclin-dependent kinases by p21

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CD95/Fas signaling in T lymphocytes induces the cell cycle control protein p21cip-1/WAF-1, which promotes apoptosis

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IFNalpha induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells

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Depletion of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances platinum drug sensitivity in human ovarian carcinoma cells

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c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1.

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The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoter

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Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein

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New functional activities for the p21 family of CDK inhibitors

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Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites

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Activation of protein kinase C triggers its ubiquitination and degradation

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The extended protein kinase C superfamily

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The long terminal repeats of human immunodeficiency virus type-1 and human T-cell leukemia virus type-I are activated by 12-O-tetradecanoylphorbol-13-acetate through different pathways

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Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members

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Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication

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Progesterone regulates transcription of the p21(WAF1) cyclin- dependent kinase inhibitor gene through Sp1 and CBP/p300.

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Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

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Activation of HTLV-I long terminal repeat by stress-inducing agents and protection of HTLV-I-infected T-cells from apoptosis by the viral tax protein

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Sp1 is involved in a protein kinase C-independent activation of human T cell leukemia virus type I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate

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Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C.

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The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

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Mammalian RNAi for the masses

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AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression

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p21-containing cyclin kinases exist in both active and inactive states

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Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes

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Transcriptional Regulation of the p21(WAF1/CIP1)Gene

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The role of the Smad3 protein in phorbol ester-induced promoter expression

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10.1038/SJ.ONC.1206782

1 reference

Europe PubMed Central

4 December 2017

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1 reference

Europe PubMed Central

4 December 2017

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