Design of quinolinedione-based geldanamycin analogues (Q44563633)

4 December 2017

Design of quinolinedione-based geldanamycin analogues (English)

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4 December 2017

3

Luke Whitesell

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4 December 2017

Robert Hargreaves

1

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4 December 2017

Cynthia L David

series ordinal

2

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4 December 2017

Edward B Skibo

series ordinal

4

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4 December 2017

language of work or name

English

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publication date

1 September 2003

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4 December 2017

4

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Bioorganic & Medicinal Chemistry Letters

inferred from page(s)

published in

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4 December 2017

13

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4 December 2017

18

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4 December 2017

3075-3078

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Hsp90 inhibitors as novel cancer chemotherapeutic agents

4 December 2017

1 reference

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Structure-based 3-D-QSAR analysis of marine indole alkaloids

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Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

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Total synthesis of (+)-geldanamycin and (-)-o-quinogeldanamycin with use of asymmetric anti- and syn-glycolate aldol reactions

1 reference

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Synthesis of the left-hand portion of geldanamycin using an anti glycolate aldol reaction

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Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

1 reference

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A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

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Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

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Heterocyclic quinones. 17. A new in vivo active antineoplastic drug: 6,7-bis(1-aziridinyl)-4-[[3-(N,N-dimethylamino)propyl]amino]-5,8- quinazolinedione

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Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm.

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A comprehensive study of the active site residues of DT-diaphorase: rational design of benzimidazolediones as DT-diaphorase substrates

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Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

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Molybdate inhibits hsp90, induces structural changes in its C-terminal domain, and alters its interactions with substrates

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Identifiers

DOI

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4 December 2017

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