Agonist-specific transactivation of phosphoinositide 3-kinase signaling pathway mediated by the dopamine D2 receptor (Q44582560)

4 December 2017

Agonist-specific transactivation of phosphoinositide 3-kinase signaling pathway mediated by the dopamine D2 receptor (English)

1 reference

4 December 2017

0 references

Venugopalan D Nair

1

1 reference

PubMed ID

12970364

4 December 2017

Stuart C Sealfon

series ordinal

2

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PubMed ID

12970364

4 December 2017

language of work or name

English

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publication date

11 September 2003

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Journal of Biological Chemistry

4 December 2017

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4 December 2017

278

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4 December 2017

47

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4 December 2017

47053-47061

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Sequence alignment of the G-protein coupled receptor superfamily

4 December 2017

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Are dopamine receptor agonists neuroprotective in Parkinson's disease?

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Slowing Parkinson's disease progression: recent dopamine agonist trials

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Seven-transmembrane receptors

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Conformation and stability of alpha-helical membrane proteins. 1. Influence of salts on conformational equilibria between active and Inactive states of rhodopsin

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Single-molecule spectroscopy of the beta(2) adrenergic receptor: observation of conformational substates in a membrane protein

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Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations.

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Agonist-receptor efficacy. II. Agonist trafficking of receptor signals

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Agonist regulation of D(2) dopamine receptor/G protein interaction. Evidence for agonist selection of G protein subtype

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Control of conformational equilibria in the human B2 bradykinin receptor. Modeling of nonpeptidic ligand action and comparison to the rhodopsin structure.

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Activation of phosphoinositide 3-kinase by D2 receptor prevents apoptosis in dopaminergic cell lines

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Superoxide Radical: An Endogenous Toxicant

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Etiology and pathogenesis of Parkinson's disease

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Apoptosis in neurodegenerative disorders

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Visualization of phosphoinositides that bind pleckstrin homology domains: calcium- and agonist-induced dynamic changes and relationship to myo-[3H]inositol-labeled phosphoinositide pools

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PI3K: downstream AKTion blocks apoptosis

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

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Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

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The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

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AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation

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Akt activation by growth factors is a multiple-step process: the role of the PH domain

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Molecular characteristics of mammalian dopamine receptors

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

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Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells

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Tyrosine kinase inhibition: an approach to drug development

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Autophosphorylation sites on the epidermal growth factor receptor.

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c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function

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Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

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Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation

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Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular Ca2+, PYK-2, and p60(src).

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Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade

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Signal characteristics of G protein-transactivated EGF receptor

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Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

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Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation

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Association between the PDGF receptor and members of the src family of tyrosine kinases

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pp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src

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Specific binding of the C-terminal Src homology 2 domain of the p85alpha subunit of phosphoinositide 3-kinase to phosphatidylinositol 3,4,5-trisphosphate. Localization and engineering of the phosphoinositide-binding motif

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Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen

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Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway

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The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor

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The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase

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A D2 class dopamine receptor transactivates a receptor tyrosine kinase to inhibit NMDA receptor transmission

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Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade.

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D(2) dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons

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Evidence for protean agonism of RX 831003 at alpha 2A-adrenoceptors by co-expression with different G alpha protein subunits

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Serotonin 5-hydroxytryptamine 2A receptor-coupled phospholipase C and phospholipase A2 signaling pathways have different receptor reserves

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Identifiers

DOI

10.1074/JBC.M303364200

1 reference

4 December 2017

1 reference

PubMed ID

12970364