Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase (Q44586157)

4 December 2017

title

Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase (English)

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4 December 2017

Miyako Masubuchi

1

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4 December 2017

Hirosato Ebiike

2

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4 December 2017

Ken-ichi Kawasaki

3

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4 December 2017

Satoshi Sogabe

4

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4 December 2017

Kenji Morikami

5

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4 December 2017

Yasuhiko Shiratori

6

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4 December 2017

Shinji Tsujii

7

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4 December 2017

Toshihiko Fujii

8

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4 December 2017

Kiyoaki Sakata

9

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4 December 2017

Michiko Hayase

10

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4 December 2017

Hidetoshi Shindoh

11

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4 December 2017

Yuko Aoki

12

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4 December 2017

Tatsuo Ohtsuka

13

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4 December 2017

Nobuo Shimma

14

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4 December 2017

language of work or name

English

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publication date

1 October 2003

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Bioorganic & Medicinal Chemistry

4 December 2017

published in

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4 December 2017

volume

11

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4 December 2017

issue

20

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4 December 2017

page(s)

4463-4478

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Metabolism-based drug interactions involving oral azole antifungals in humans

4 December 2017

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7 January 2021

32 Functional significance of myristoyl moiety in N-myristoyl proteins

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Palmitoylation of p59fyn is reversible and sufficient for plasma membrane association

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7 January 2021

Purification and characterization of yeast myristoyl CoA:protein N-myristoyltransferase.

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7 January 2021

Binding of acylated peptides and fatty acids to phospholipid vesicles: pertinence to myristoylated proteins

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7 January 2021

Electrostatic interaction of myristoylated proteins with membranes: simple physics, complicated biology

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7 January 2021

Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins

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7 January 2021

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

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7 January 2021

Genetic and biochemical studies of protein N-myristoylation

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7 January 2021

ADP ribosylation factor is an essential protein in Saccharomyces cerevisiae and is encoded by two genes

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A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole

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7 January 2021

Genetic studies reveal that myristoylCoA:protein N-myristoyltransferase is an essential enzyme in Candida albicans

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7 January 2021

Targeted gene replacement demonstrates that myristoyl-CoA: protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans.

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7 January 2021

Tetracycline-regulatable system to tightly control gene expression in the pathogenic fungus Candida albicans

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7 January 2021

Design and syntheses of potent and selective dipeptide inhibitors of Candida albicans myristoyl-CoA:protein N-myristoyltransferase

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7 January 2021

Conformationally constrained [p-(omega-aminoalkyl)phenacetyl]-L-seryl-L-lysyl dipeptide amides as potent peptidomimetic inhibitors of Candida albicans and human myristoyl-CoA:protein N-myristoyl transferase

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7 January 2021

Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifung

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7 January 2021

Novel biologically active nonpeptidic inhibitors of myristoylCoA:protein N-myristoyltransferase

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7 January 2021

Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: protein N-myristoyltransferase: a new approach to antifungal therapy

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7 January 2021

N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase

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7 January 2021

Genetic and biochemical studies establish that the fungicidal effect of a fully depeptidized inhibitor of Cryptococcus neoformans myristoyl-CoA:protein N-myristoyltransferase (Nmt) is Nmt-dependent.

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7 January 2021

Synthesis and antifungal activities of myristic acid analogs

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7 January 2021

Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase

1 reference

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7 January 2021

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 1.

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7 January 2021

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2.

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7 January 2021

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3.

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7 January 2021

Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors

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7 January 2021

Cassette dosing approach and quantitative structure-pharmacokinetic relationship study of antifungal N-myristoyltransferase inhibitors

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7 January 2021

Synthesis and antifungal activities of novel 1,3-beta-D-glucan synthase inhibitors. Part 1.

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7 January 2021

In-vitro activity of SCH39304 in comparison with amphotericin B and fluconazole

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7 January 2021

Simultaneous pharmacokinetic screening of a mixture of compounds in the dog using API LC/MS/MS analysis for increased throughput

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7 January 2021

The simultaneous determination of mixtures of drug candidates by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry as an in vivo drug screening procedure

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7 January 2021

Demonstration of high- and low-affinity beta-adrenergic receptors in slide-mounted sections of rat and human brain

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7 January 2021

Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs

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7 January 2021

The nature of .pi.-.pi. interactions

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7 January 2021

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

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7 January 2021

Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors

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7 January 2021

Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene.

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7 January 2021

A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazole.

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7 January 2021

Sensitive bioassay for determination of fluconazole concentrations in plasma using a Candida albicans mutant hypersusceptible to azoles.

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7 January 2021

10.1016/S0968-0896(03)00429-2

Identifiers

DOI

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4 December 2017

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