Toll-like receptor 9 triggers an innate immune response to helper-dependent adenoviral vectors. (Q44592739)

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24 December 2019

title

Toll-like receptor 9 triggers an innate immune response to helper-dependent adenoviral vectors (English)

1 reference

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24 December 2019

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1

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24 December 2019

Nicola Brunetti-Pierri

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24 December 2019

author name string

Michael P Seiler

2

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24 December 2019

Viraj Mane

3

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24 December 2019

Christian Clarke

5

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24 December 2019

Terry K Bertin

6

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24 December 2019

John R Rodgers

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24 December 2019

Brendan Lee

8

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24 December 2019

publication date

1 February 2007

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24 December 2019

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24 December 2019

volume

15

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24 December 2019

issue

2

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24 December 2019

page(s)

378-385

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Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo

24 December 2019

cites work

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High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity

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7 January 2021

Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo

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Blunting of immune responses to adenoviral vectors in mouse liver and lung with CTLA4Ig.

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Sustained phenotypic correction of canine hemophilia B after systemic administration of helper-dependent adenoviral vector

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Helper-dependent adenoviral gene therapy mediates long-term correction of the clotting defect in the canine hemophilia A model

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Long-term correction of ornithine transcarbamylase deficiency by WPRE-mediated overexpression using a helper-dependent adenovirus

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7 January 2021

Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons

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7 January 2021

Long-term stable correction of low-density lipoprotein receptor-deficient mice with a helper-dependent adenoviral vector expressing the very low-density lipoprotein receptor

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7 January 2021

Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector

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Toxicological comparison of E2a-deleted and first-generation adenoviral vectors expressing alpha1-antitrypsin after systemic delivery

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Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons

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Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates.

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7 January 2021

Modulation of TNFalpha, a determinant of acute toxicity associated with systemic delivery of first-generation and helper-dependent adenoviral vectors

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7 January 2021

The innate immune response to adenovirus vectors

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7 January 2021

Drosophila innate immunity: an evolutionary perspective

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7 January 2021

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

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7 January 2021

Toll-like receptors in the induction of the innate immune response

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7 January 2021

The interface between innate and adaptive immunity

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7 January 2021

Innate immune recognition of viral infection

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7 January 2021

Innate immune recognition

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7 January 2021

Toll-like receptor signalling

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7 January 2021

Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

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7 January 2021

A Toll-like receptor recognizes bacterial DNA

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7 January 2021

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

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7 January 2021

TLR9 is localized in the endoplasmic reticulum prior to stimulation

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7 January 2021

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

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7 January 2021

Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.

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7 January 2021

CpG oligodeoxynucleotides induce murine macrophages to up-regulate chemokine mRNA expression

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7 January 2021

Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9.

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7 January 2021

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells

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7 January 2021

Rapid Kupffer cell death after intravenous injection of adenovirus vectors

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7 January 2021

Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors

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7 January 2021

Viral activation of macrophages through TLR-dependent and -independent pathways

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7 January 2021

Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs

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7 January 2021

Inhibitory oligonucleotides specifically block effects of stimulatory CpG oligonucleotides in B cells

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7 January 2021

Simultaneous CAR- and alpha V integrin-binding ablation fails to reduce Ad5 liver tropism

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7 January 2021

Adenovirus endocytosis.

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7 January 2021

Mechanism by which calcium phosphate coprecipitation enhances adenovirus-mediated gene transfer

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7 January 2021

Development and characterization of novel empty adenovirus capsids and their impact on cellular gene expression

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7 January 2021

Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-kappaB, ERK and p38 MAPK signal pathways

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7 January 2021

Sublethal infection of C57BL/6 mice with Salmonella enterica Serovar Typhimurium leads to an increase in levels of Toll-like receptor 1 (TLR1), TLR2, and TLR9 mRNA as well as a decrease in levels of TLR6 mRNA in infected organs

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7 January 2021

Adenovirus type-5 entry and disassembly followed in living cells by FRET, fluorescence anisotropy, and FLIM.

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7 January 2021

Generation of helper-dependent adenoviral vectors by homologous recombination

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7 January 2021

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7 January 2021

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7 January 2021