Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARgamma2 (P12A) polymorphisms (Q44629006)

4 December 2017

Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARgamma2 (P12A) polymorphisms (English)

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4 December 2017

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8

L Frittitta

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R Baratta

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R Di Paola

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D Spampinato

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G Fini

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A Marucci

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A Coco

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R Vigneri

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V Trischitta

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language of work or name

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22 October 2003

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Journal of Molecular Medicine

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81

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11

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718-723

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https://scigraph.springernature.com/pub.10.1007/s00109-003-0466-3

4 December 2017

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A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

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The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects

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12 December 2020

Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study

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The Pro12Ala variant of peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) is associated with measures of obesity in Mexican Americans

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12 December 2020

The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance

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12 December 2020

Interaction effect between common polymorphisms in PPARgamma2 (Pro12Ala) and insulin receptor substrate 1 (Gly972Arg) on insulin sensitivity

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12 December 2020

Effect of the peroxisome proliferator-activated receptor-gamma 2 pro(12)ala variant on obesity, glucose homeostasis, and blood pressure in members of familial type 2 diabetic kindreds

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Digenic inheritance of severe insulin resistance in a human pedigree

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Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations

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The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121)

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12 December 2020

Genetic variation in the peroxisome proliferator-activated receptor-gamma2 gene (Pro12Ala) affects metabolic responses to weight loss and subsequent weight regain

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Glucose clamp technique: a method for quantifying insulin secretion and resistance

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The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

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12 December 2020

Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene is associated with increased antilipolytic insulin sensitivity

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12 December 2020

The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes

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12 December 2020

A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance

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12 December 2020

Strategies and prospects for finding insulin resistance genes

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12 December 2020

The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia

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12 December 2020

Banting lecture 1988. Role of insulin resistance in human disease

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12 December 2020

A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance

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12 December 2020

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

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12 December 2020

10.1007/S00109-003-0466-3

Identifiers

DOI

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4 December 2017

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