Interactions of quinones with thioredoxin reductase: a challenge to the antioxidant role of the mammalian selenoprotein (Q44646961)

5 December 2017

Interactions of quinones with thioredoxin reductase: a challenge to the antioxidant role of the mammalian selenoprotein (English)

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5 December 2017

Narimantas Cenas

1

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5 December 2017

Henrikas Nivinskas

2

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5 December 2017

Zilvinas Anusevicius

3

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5 December 2017

Jonas Sarlauskas

4

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5 December 2017

Florence Lederer

5

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5 December 2017

Elias S J Arnér

6

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5 December 2017

language of work or name

English

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publication date

6 November 2003

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Journal of Biological Chemistry

5 December 2017

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5 December 2017

279

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5 December 2017

4

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5 December 2017

2583-2592

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Physiological functions of thioredoxin and thioredoxin reductase

5 December 2017

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Reactive oxygen species, antioxidants, and the mammalian thioredoxin system

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The mechanism of high Mr thioredoxin reductase from Drosophila melanogaster

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Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster

21 January 2018

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Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

21 January 2018

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Active sites of thioredoxin reductases: why selenoproteins?

21 January 2018

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Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme

21 January 2018

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The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli

21 January 2018

1 reference

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Thioredoxin reductase as a pathophysiological factor and drug target

21 January 2018

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Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant

21 January 2018

1 reference

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A novel antioxidant mechanism of ebselen involving ebselen diselenide, a substrate of mammalian thioredoxin and thioredoxin reductase

21 January 2018

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Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase

21 January 2018

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The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress

21 January 2018

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Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium

21 January 2018

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Monitoring antisense oligodeoxynucleotide activity in hematopoietic cells

21 January 2018

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The 58 kDa mouse selenoprotein is a BCNU-sensitive thioredoxin reductase.

21 January 2018

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Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex

21 January 2018

1 reference

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Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds

21 January 2018

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Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia

21 January 2018

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Molecular mechanisms of quinone cytotoxicity

21 January 2018

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Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones

21 January 2018

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The mechanism of the quinone reductase reaction of pig heart lipoamide dehydrogenase

21 January 2018

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2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

21 January 2018

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Enzymatic reduction of alloxan by thioredoxin and NADPH-thioredoxin reductase

21 January 2018

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High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes

21 January 2018

1 reference

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Arabidopsis thaliana NAPHP thioredoxin reductase. cDNA characterization and expression of the recombinant protein in Escherichia coli.

21 January 2018

1 reference

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Potential central nervous system antitumor agents. Aziridinylbenzoquinones.

21 January 2018

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A 'branched' mechanism of the reverse reaction of yeast glutathione reductase. An estimation of the enzyme standard potential values from the steady-state kinetics data

21 January 2018

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Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme

21 January 2018

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The single mutation Trp35-->Ala in the 35-40 redox site of Chlamydomonas reinhardtii thioredoxin h affects its biochemical activity and the pH dependence of C36-C39 1H-13C NMR.

21 January 2018

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DT-diaphorase-catalysed reduction of 1,4-naphthoquinone derivatives and glutathionyl-quinone conjugates. Effect of substituents on autoxidation rates

21 January 2018

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Catalysis of diaphorase reactions by Mycobacterium tuberculosis lipoamide dehydrogenase occurs at the EH4 level

21 January 2018

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Bioreductive activation of quinones: redox properties and thiol reactivity

21 January 2018

1 reference

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16 Product inhibition and abortive complex formation

21 January 2018

1 reference

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Cytotoxicity of RH1 and related aziridinylbenzoquinones: involvement of activation by NAD(P)H:quinone oxidoreductase (NQO1) and oxidative stress.

21 January 2018

1 reference

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Interaction of quinones with Arabidopsis thaliana thioredoxin reductase

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M310292200

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5 December 2017

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