Alpha-thrombin-mediated phosphatidylinositol 3-kinase activation through release of Gbetagamma dimers from Galphaq and Galphai2. (Q44688373)

5 December 2017

Alpha-thrombin-mediated phosphatidylinositol 3-kinase activation through release of Gbetagamma dimers from Galphaq and Galphai2. (English)

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5 December 2017

Reema Goel

1

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5 December 2017

Polly J Phillips-Mason

2

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5 December 2017

Alice Gardner

3

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5 December 2017

Daniel M Raben

4

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5 December 2017

Joseph J Baldassare

5

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5 December 2017

language of work or name

English

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publication date

9 December 2003

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Journal of Biological Chemistry

5 December 2017

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5 December 2017

279

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5 December 2017

8

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5 December 2017

6701-6710

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How the protease thrombin talks to cells

5 December 2017

1 reference

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How receptors talk to trimeric G proteins

21 January 2018

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Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

21 January 2018

1 reference

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Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

Diversity of G proteins in signal transduction

21 January 2018

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Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins

21 January 2018

1 reference

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G12 requirement for thrombin-stimulated gene expression and DNA synthesis in 1321N1 astrocytoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

A novel role for Gq alpha in alpha-thrombin-mediated mitogenic signalling pathways

21 January 2018

1 reference

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G alpha minigenes expressing C-terminal peptides serve as specific inhibitors of thrombin-mediated endothelial activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells

21 January 2018

1 reference

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Thrombin receptors activate G(o) proteins in endothelial cells to regulate intracellular calcium and cell shape changes.

21 January 2018

1 reference

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The thrombin receptor second cytoplasmic loop confers coupling to Gq-like G proteins in chimeric receptors. Additional evidence for a common transmembrane signaling and G protein coupling mechanism in G protein-coupled receptors.

21 January 2018

1 reference

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Ablation of Go alpha-subunit results in a transformed phenotype and constitutively active phosphatidylcholine-specific phospholipase C.

21 January 2018

1 reference

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Ablation of Goalpha overrides G1 restriction point control through Ras/ERK/cyclin D1-CDK activities

21 January 2018

1 reference

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Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2.

21 January 2018

1 reference

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Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells. A direct evaluation of selectivity in receptor.G protein coupling

21 January 2018

1 reference

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Analysis of G protein activation in Sf9 and mammalian cells by agonist-promoted [35S]GTP gamma S binding

21 January 2018

1 reference

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A dominant-negative strategy for studying roles of G proteins in vivo.

21 January 2018

1 reference

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Inhibition of subsets of G protein-coupled receptors by empty mutants of G protein alpha subunits in g(o), G(11), and G(16).

21 January 2018

1 reference

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New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

21 January 2018

1 reference

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Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking.

21 January 2018

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Short-range RNA-RNA crosslinking methods to determine rRNA structure and interactions

21 January 2018

1 reference

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Cellular consequences of thrombin-receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

beta-Arrestin 1 couples thrombin to the rapid activation of the Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

G protein specificity: traffic direction required.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

Selective activation of effector pathways by brain-specific G protein beta5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

Functions of lipid rafts in biological membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

Sphingolipid signalling domains floating on rafts or buried in caves?

21 January 2018

1 reference

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G protein selectivity is a determinant of RGS2 function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

Membrane microdomains and caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

Organization of G proteins and adenylyl cyclase at the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

G protein subunits and cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation

21 January 2018

1 reference

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Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110beta is synergistically activated by the betagamma subunits of G proteins and phosphotyrosyl peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

Involvement of pertussis toxin-sensitive and -insensitive G proteins in alpha-thrombin signalling on cultured human vascular smooth muscle cells

21 January 2018

1 reference

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Galpha(q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cells

21 January 2018

1 reference

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alpha-Thrombin induces rapid and sustained Akt phosphorylation by beta-arrestin1-dependent and -independent mechanisms, and only the sustained Akt phosphorylation is essential for G1 phase progression

21 January 2018

1 reference

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Phosphatidylinositol 3-kinase activity regulates alpha -thrombin-stimulated G1 progression by its effect on cyclin D1 expression and cyclin-dependent kinase 4 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308753200

21 January 2018

Identifiers

DOI

10.1074/JBC.M308753200

1 reference

5 December 2017

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