STA-21, a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis (Q44689404)

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scientific article published in April 2014

Language	Label	Description	Also known as
English	STA-21, a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis	scientific article published in April 2014

Statements

scholarly article

1 reference

Europe PubMed Central

5 December 2017

STA-21, a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis (English)

1 reference

Europe PubMed Central

5 December 2017

rheumatoid arthritis

1 reference

based on heuristic

inferred from title

author name string

Jin-Sil Park

1

1 reference

Europe PubMed Central

5 December 2017

Seung-Ki Kwok

2

1 reference

Europe PubMed Central

5 December 2017

Mi-Ae Lim

3

1 reference

Europe PubMed Central

5 December 2017

Eun-Kyung Kim

4

1 reference

Europe PubMed Central

5 December 2017

Jun-Geol Ryu

5

1 reference

Europe PubMed Central

5 December 2017

Sung-Min Kim

6

1 reference

Europe PubMed Central

5 December 2017

Hye-Joa Oh

7

1 reference

Europe PubMed Central

5 December 2017

Ji Hyeon Ju

8

1 reference

Europe PubMed Central

5 December 2017

Sung-Hwan Park

9

1 reference

Europe PubMed Central

5 December 2017

Ho-Youn Kim

10

1 reference

Europe PubMed Central

5 December 2017

Mi-La Cho

11

1 reference

Europe PubMed Central

5 December 2017

publication date

1 April 2014

1 reference

Europe PubMed Central

5 December 2017

Arthritis & Rheumatology

1 reference

Europe PubMed Central

5 December 2017

66

1 reference

Europe PubMed Central

5 December 2017

4

1 reference

Europe PubMed Central

5 December 2017

918-929

1 reference

Europe PubMed Central

5 December 2017

Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors?

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Joint erosion in rheumatoid arthritis: interactions between tumour necrosis factor alpha, interleukin 1, and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclasts

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Differentiation and function of pro-inflammatory Th17 cells

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Th17 cells in human disease.

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Cells of the synovium in rheumatoid arthritis. T lymphocytes.

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

STAT3 regulates cytokine-mediated generation of inflammatory helper T cells

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis.

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

A four-step model for the IL-6 amplifier, a regulator of chronic inflammations in tissue-specific MHC class II-associated autoimmune diseases

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

TWEAK promotes osteoclastogenesis in rheumatoid arthritis.

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Grape-seed proanthocyanidin extract as suppressors of bone destruction in inflammatory autoimmune arthritis

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

The regulation of Foxp3 expression in regulatory CD4(+)CD25(+)T cells: multiple pathways on the road

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Retinoic acid attenuates rheumatoid inflammation in mice

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Osteoimmunology: interactions of the bone and immune system

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Osteoimmunology: cytokines and the skeletal system

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Regulatory T cells: how do they suppress immune responses?

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

The role of interleukin-17 in the pathogenesis of rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Breaking old paradigms: Th17 cells in autoimmune arthritis

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

The yin and yang of regulatory T cells and inflammation in RA.

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Targeting kinases: a new approach to treating inflammatory rheumatic diseases

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

The course of radiologic damage during the first six years of rheumatoid arthritis.

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Course of radiographic damage over 10 years in a cohort with early rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Ten year outcome in a cohort of patients with early rheumatoid arthritis: health status, disease process, and damage

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroi

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Specific inhibition of Stat3 signal transduction by PIAS3

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis

1 reference

https://api.crossref.org/works/10.1002%2FART.38305

21 January 2018

Identifiers

10.1002/ART.38305

1 reference

Europe PubMed Central

5 December 2017

1 reference

Europe PubMed Central

5 December 2017

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