Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions (Q44691515)

5 December 2017

Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions (English)

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5 December 2017

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16

Shun Shimohama

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Hideyuki Sawada

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5 December 2017

Ryuichi Kohno

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Takeshi Kihara

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5 December 2017

Yasuhiko Izumi

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5 December 2017

Noriko Sakka

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5 December 2017

Miki Nakanishi

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Kentarou Yamakawa

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5 December 2017

Hiroshi Shibasaki

10

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5 December 2017

Noriyuki Yamamoto

11

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5 December 2017

Akinori Akaike

12

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5 December 2017

Masatoshi Inden

13

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5 December 2017

Yoshihisa Kitamura

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Takashi Taniguchi

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5 December 2017

language of work or name

English

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publication date

12 December 2003

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Journal of Biological Chemistry

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5 December 2017

279

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11

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5 December 2017

10710-10719

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

5 December 2017

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Brain proteasomal function in sporadic Parkinson's disease and related disorders

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Proteasomal function is impaired in substantia nigra in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Clinical and pathologic abnormalities in a family with parkinsonism and parkin gene mutations.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Lewy bodies and parkinsonism in families with parkin mutations

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Mitochondrial complex I deficiency in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308434200

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium ion on activities of the enzymes in the electron transport system in mouse brain

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308434200

Cytoplasmic aggregates of phosphorylated extracellular signal-regulated protein kinases in Lewy body diseases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Bcl-2 and Bax proteins in Lewy bodies from patients with Parkinson's disease and Diffuse Lewy body disease.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308434200

Cell adhesion protects c-Raf-1 against ubiquitin-dependent degradation by the proteasome

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

Geldanamycin-induced destabilization of Raf-1 involves the proteasome

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308434200

The Ras/phosphatidylinositol 3-kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308434200

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308434200

21 January 2018

Identifiers

DOI

10.1074/JBC.M308434200

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5 December 2017

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