Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway. (Q44777524)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14985429%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

title

Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14985429%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

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He-Jin Lee

1

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24 November 2019

Farnaz Khoshaghideh

series ordinal

2

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24 November 2019

Smita Patel

series ordinal

3

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24 November 2019

Seung-Jae Lee

series ordinal

4

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24 November 2019

language of work or name

English

0 references

publication date

1 February 2004

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24 November 2019

published in

Journal of Neuroscience

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24 November 2019

volume

24

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24 November 2019

issue

8

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24 November 2019

page(s)

1888-1896

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Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia

24 November 2019

cites work

1 reference

12 December 2020

Degradation of alpha-synuclein by proteasome

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12 December 2020

Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution

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Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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A Drosophila model of Parkinson's disease

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Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

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Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

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The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review

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Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration

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Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

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12 December 2020

Alpha-synuclein and neurodegenerative diseases

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12 December 2020

Induction of alpha-synuclein aggregation by intracellular nitrative insult.

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12 December 2020

Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations

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12 December 2020

Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form

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12 December 2020

Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors

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12 December 2020

alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

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12 December 2020

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

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DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death

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12 December 2020

Neuronal loss and brain atrophy in mice lacking cathepsins B and L

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12 December 2020

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

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12 December 2020

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

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12 December 2020

Intracellular deposition, microtubule destabilization, and transport failure: an "early" pathogenic cascade leading to synaptic decline

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12 December 2020

Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes.

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12 December 2020

Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells

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12 December 2020

Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion

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12 December 2020

A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice

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12 December 2020

Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis.

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12 December 2020

The neuropathogenic contributions of lysosomal dysfunction

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12 December 2020

Endoproteolytic activity of the proteasome

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12 December 2020

Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis

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12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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12 December 2020

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

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12 December 2020

Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease

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12 December 2020

Are ubiquitination pathways central to Parkinson's disease?

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12 December 2020

alpha-Synuclein locus triplication causes Parkinson's disease

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12 December 2020

Autophagy and related mechanisms of lysosome-mediated protein degradation

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12 December 2020

Degeneration of neuronal processes in rats induced by a protease inhibitor, leupeptin

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12 December 2020

A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins

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12 December 2020

Lysosome instability in aged rat brain

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12 December 2020

Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells

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12 December 2020

The effect of aging on lysosomal permeability in nerve cells of the central nervous system. An enzyme histochemical study in rat

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12 December 2020

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

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12 December 2020

Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles.

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12 December 2020

Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

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12 December 2020

Anti-ubiquitin immunoreactivity associates with pyramidal cell death induced by intraventricular infusion of leupeptin in rat hippocampus.

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12 December 2020

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1 reference

12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

12 December 2020

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

12 December 2020

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

12 December 2020

10.1523/JNEUROSCI.3809-03.2004

Identifiers

DOI

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24 November 2022

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24 November 2019

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