Overexpression of glutathione peroxidase 4 prevents β-cell dysfunction induced by prolonged elevation of lipids in vivo (Q44906014)

7 December 2017

Overexpression of glutathione peroxidase 4 prevents β-cell dysfunction induced by prolonged elevation of lipids in vivo (English)

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7 December 2017

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8

Adria Giacca

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7 December 2017

1

Khajag Koulajian

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7 December 2017

Alexander Ivovic

2

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7 December 2017

Kaitai Ye

3

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7 December 2017

Tejas Desai

4

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7 December 2017

Anu Shah

5

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7 December 2017

I George Fantus

6

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7 December 2017

Qitao Ran

7

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7 December 2017

21 May 2013

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American Journal of Physiology - Endocrinology and Metabolism

7 December 2017

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7 December 2017

305

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7 December 2017

2

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7 December 2017

E254-62

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Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart

7 December 2017

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

PHGPx and phospholipase A2/GPx: comparative importance on the reduction of hydroperoxides in rat liver mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Tissue-specific functions of individual glutathione peroxidases

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Free fatty acid-mediated impairment of glucose-stimulated insulin secretion in nondiabetic Oji-Cree individuals from the Sandy Lake community of Ontario, Canada: a population at very high risk for developing type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Ebselen effects on MPTP-induced neurotoxicity.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

The disposition index: adjustment for peripheral vs. hepatic insulin sensitivity?

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Redox regulation of NF-kappa B activation

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes?

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Chemistry and biochemistry of lipid peroxidation products.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Effects of weight loss and reduced hyperglycemia on the kinetics of insulin secretion in obese non-insulin dependent diabetes mellitus

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

beta-Cell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Lipid peroxidation and mechanisms of toxicity

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Enhanced expression of glutathione peroxidase protects islet beta cells from hypoxia-reoxygenation

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Prolonged increase of plasma non-esterified fatty acids fully abolishes the stimulatory effect of 24 hours of moderate hyperglycaemia on insulin sensitivity and pancreatic beta-cell function in obese men.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

The interaction of oxidative stress response with cytokines in the thyrotoxic rat: is there a link?

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Reactions of 4-hydroxynonenal with proteins and cellular targets

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Embryonic fibroblasts from Gpx4+/- mice: a novel model for studying the role of membrane peroxidation in biological processes

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Pancreatic islet beta-cell and oxidative stress: the importance of glutathione peroxidase

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Coupling of beta-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Beta cell (dys)function in non-diabetic offspring of diabetic patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Diet-induced type II diabetes in C57BL/6J mice

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic beta-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

The role of selenium peroxidases in the protection against oxidative damage of membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Oral taurine but not N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

The effect of high-dose sodium salicylate on chronically elevated plasma nonesterified fatty acid-induced insulin resistance and β-cell dysfunction in overweight and obese nondiabetic men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

Elevated circulating free fatty acids levels causing pancreatic islet cell dysfunction through oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00481.2012

10.1152/AJPENDO.00481.2012

21 January 2018

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DOI

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7 December 2017

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