Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis. (Q44911297)

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29 December 2019

title

Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis (English)

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29 December 2019

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5

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Michel Neidhart

4

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29 December 2019

author name string

J Schedel

1

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C A Seemayer

2

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T Pap

3

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B A Michel

6

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R E Gay

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U Müller-Ladner

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S Gay

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W Zacharias

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publication date

1 July 2004

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29 December 2019

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volume

11

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page(s)

1040-1047

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issue

13

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3302265

29 December 2019

exact match

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1 reference

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Activation of synovial fibroblasts in rheumatoid arthritis: lack of Expression of the tumour suppressor PTEN at sites of invasive growth and destruction

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Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis

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Differential expression of cathepsins B and L compared with matrix metalloproteinases and their respective inhibitors in rheumatoid arthritis and osteoarthritis: a parallel investigation by semiquantitative reverse transcriptase-polymerase chain rea

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Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis

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Macrophage cathepsin L, a factor in the erosion of subchondral bone in rheumatoid arthritis

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Cathepsins B and L are markers for clinically invasive types of meningiomas

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Inhibition of cartilage destruction by double gene transfer of IL-1Ra and IL-10 involves the activin pathway

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Antisense RNA inhibition of cathepsin L expression reduces tumorigenicity of malignant cells

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Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype

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Ribozyme-based gene cleavage approach to chronic arthritis associated with human T cell leukemia virus type I: induction of apoptosis in synoviocytes by ablation of HTLV-I tax protein

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Inhibition of hepatitis C virus (HCV)-RNA-dependent translation and replication of a chimeric HCV poliovirus using synthetic stabilized ribozymes

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The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

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Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts

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Anti-interleukin-1 and anti-CD44 interventions producing significant inhibition of cartilage destruction in an in vitro model of cartilage invasion by rheumatoid arthritis synovial fibroblasts

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Susceptibility of the cartilage collagens types II, IX and XI to degradation by the cysteine proteinases, cathepsins B and L

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Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization

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Identifiers

DOI

10.1038/SJ.GT.3302265

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15164093%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

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