Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L. (Q44946042)

7 December 2017

Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L. (English)

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suppression by virus of host PKR signaling

7 December 2017

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Gene Ontology release 2020-05-02

vaccinia virus

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Jeffrey O Langland

1

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PubMed ID

15207627

7 December 2017

Bertram L Jacobs

series ordinal

2

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PubMed ID

15207627

7 December 2017

language of work or name

English

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publication date

1 July 2004

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7 December 2017

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7 December 2017

324

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7 December 2017

2

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7 December 2017

419-429

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RNA editing and hypermutation by adenosine deamination

7 December 2017

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Distinct patterns of IFN sensitivity observed in cells infected with vaccinia K3L- and E3L- mutant viruses

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1 reference

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Both carboxy- and amino-terminal domains of the vaccinia virus interferon resistance gene, E3L, are required for pathogenesis in a mouse model

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1 reference

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Latently expressed human herpesvirus 8-encoded interferon regulatory factor 2 inhibits double-stranded RNA-activated protein kinase

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Activation of RNase L by 2',5'-oligoadenylates. Kinetic characterization.

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Identification of a conserved motif that is necessary for binding of the vaccinia virus E3L gene products to double-stranded RNA.

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1 reference

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The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase

7 January 2021

1 reference

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The double-stranded RNA-activated kinase, PKR, can phosphorylate hepatitis D virus small delta antigen at functional serine and threonine residues

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1 reference

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Signals that dictate nuclear, nucleolar, and cytoplasmic shuttling of the gamma(1)34.5 protein of herpes simplex virus type 1

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Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2 alpha

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1 reference

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Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase

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1 reference

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Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

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1 reference

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Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible

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Ultrastructural localization of phosphorylated eIF2alpha [eIF2alpha(P)] in rat dorsal hippocampus during reperfusion

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RNA binding and modulation of PKR activity.

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Perk is essential for translational regulation and cell survival during the unfolded protein response

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Vaccinia virus complement-control protein prevents antibody-dependent complement-enhanced neutralization of infectivity and contributes to virulence

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1 reference

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Nuclear localization of the interferon-inducible protein kinase PKR in human cells and transfected mouse cells

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Replication of a cytopathic strain of bovine viral diarrhea virus activates PERK and induces endoplasmic reticulum stress-mediated apoptosis of MDBK cells

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pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells

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A role for Z-DNA binding in vaccinia virus pathogenesis

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Eukaryotic initiation factor eIF2.

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Poxviral mimicry of complement and chemokine system components: what's the end game?

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1 reference

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Inhibition of the complement cascade by the major secretory protein of vaccinia virus

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1 reference

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Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation

7 January 2021

1 reference

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The role of the PKR-inhibitory genes, E3L and K3L, in determining vaccinia virus host range

7 January 2021

1 reference

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Localization of eukaryotic initiation factor 2 in neuron primary cultures and established cell lines.

7 January 2021

1 reference

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Levels, phosphorylation status and cellular localization of translational factor eIF2 in gastrointestinal carcinomas

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1 reference

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Translational initiation factor eIF-2 subcellular levels and phosphorylation status in the developing rat brain.

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1 reference

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Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

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The regulation of the protein kinase PKR by RNA.

7 January 2021

1 reference

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Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3: role of complex formation and the E3 N-terminal domain

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1 reference

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7 January 2021

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Complementation of vaccinia virus deleted of the E3L gene by mutants of E3L.

7 January 2021

1 reference

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Role of the vaccinia virus E3L and K3L gene products in rescue of VSV and EMCV from the effects of IFN-alpha

7 January 2021

1 reference

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Adenovirus infection targets the cellular protein kinase CK2 and RNA-activated protein kinase (PKR) into viral inclusions of the cell nucleus

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1 reference

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A conserved double-stranded RNA-binding domain

7 January 2021

1 reference

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Nucleocytoplasmic distribution of human RNA-editing enzyme ADAR1 is modulated by double-stranded RNA-binding domains, a leucine-rich export signal, and a putative dimerization domain.

7 January 2021

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The emerging roles of translation factor eIF4E in the nucleus

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1 reference

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Three leucine-rich sequences and the N-terminal region of double-stranded RNA-activated protein kinase (PKR) are responsible for its cytoplasmic localization.

7 January 2021

1 reference

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DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45

7 January 2021

1 reference

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Brefeldin A inhibits vaccinia virus envelopment but does not prevent normal processing and localization of the putative envelopment receptor P37.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.03.012

Nuclear localization of a double-stranded RNA-binding protein encoded by the vaccinia virus E3L gene

7 January 2021

1 reference

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The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.03.012

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.VIROL.2004.03.012

1 reference

7 December 2017

1 reference

PubMed ID

15207627