Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing TNF-alpha induction of p38 and p42/p44 mitogen-activated protein kinases (Q45057632)

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scientific article published on 9 September 2004

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English	Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing TNF-alpha induction of p38 and p42/p44 mitogen-activated protein kinases	scientific article published on 9 September 2004

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 December 2017

Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing TNF-alpha induction of p38 and p42/p44 mitogen-activated protein kinases (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 December 2017

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(RS)-rosiglitazone

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insulin resistance

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author name string

R Hernandez

1

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Europe PubMed Central

PubMed publication ID

9 December 2017

T Teruel

2

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Europe PubMed Central

PubMed publication ID

9 December 2017

C de Alvaro

3

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Europe PubMed Central

PubMed publication ID

9 December 2017

M Lorenzo

4

1 reference

Europe PubMed Central

PubMed publication ID

9 December 2017

publication date

9 September 2004

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Europe PubMed Central

PubMed publication ID

9 December 2017

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Europe PubMed Central

PubMed publication ID

9 December 2017

47

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Europe PubMed Central

PubMed publication ID

9 December 2017

9

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Europe PubMed Central

PubMed publication ID

9 December 2017

1615-1624

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Europe PubMed Central

PubMed publication ID

9 December 2017

Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

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https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

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PLCgamma participates in insulin stimulation of glucose uptake through activation of PKCzeta in brown adipocytes

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https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

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IGF-I is a mitogen involved in differentiation-related gene expression in fetal rat brown adipocytes

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https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

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Pioglitazone ameliorates tumor necrosis factor-alpha-induced insulin resistance by a mechanism independent of adipogenic activity of peroxisome proliferator--activated receptor-gamma

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https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

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A central role for JNK in obesity and insulin resistance

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https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I and insulin induce adipogenic-related gene expression in fetal brown adipocyte primary cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

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Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

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A PPAR agonist improves TNF-alpha-induced insulin resistance of adipose tissue in mice

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https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

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Mapping of early signaling events in tumor necrosis factor-alpha -mediated lipolysis in human fat cells.

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https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

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PPARalpha activation by Wy 14643 induces transactivation of the rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARgamma-mediated increases in UCP-1 mRNA levels induced by rosiglitazone in fetal rat brown adipocytes

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https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

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IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

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Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

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Rosiglitazone produces insulin sensitisation by increasing expression of the insulin receptor and its tyrosine kinase activity in brown adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

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Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

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Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

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Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

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Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

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Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

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Okadaic acid inhibits insulin-induced glucose transport in fetal brown adipocytes in an Akt-independent and protein kinase C zeta-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potentiation of glucose uptake in 3T3-L1 adipocytes by PPAR gamma agonists is maintained in cells expressing a PPAR gamma dominant-negative mutant: evidence for selectivity in the downstream responses to PPAR gamma activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

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Mechanisms of TNF-alpha-induced insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

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Regulation of glucose transport and insulin signaling by troglitazone or metformin in adipose tissue of type 2 diabetic subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

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p38 mitogen-activated protein kinase mediates tumor necrosis factor-alpha-induced apoptosis in rat fetal brown adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

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Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

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Rosiglitazone, an agonist of peroxisome-proliferator-activated receptor gamma (PPARgamma), decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

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Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

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Tumor necrosis factor alpha inhibits signaling from the insulin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serine phosphorylation of insulin receptor substrate-1: a novel target for the reversal of insulin resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin/IGF-I rescues immortalized brown adipocytes from apoptosis down-regulating Bcl-xS expression, in a PI 3-kinase- and map kinase-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of PI 3-kinase and RAS blocks IGF-I and insulin-induced uncoupling protein 1 gene expression in brown adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms involved in tumor necrosis factor-alpha induction of insulin resistance and its reversal by thiazolidinedione(s).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secretion of tumor necrosis factor-alpha shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF-alpha induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3' kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPAR gamma and the treatment of insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Troglitazone Antagonizes Tumor Necrosis Factor-α-induced Reprogramming of Adipocyte Gene Expression by Inhibiting the Transcriptional Regulatory Functions of NF-κB

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes: implication of the p80 tumor necrosis factor receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant p38 mitogen-activated protein kinase signalling in skeletal muscle from Type 2 diabetic patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor-alpha causes insulin receptor substrate-2-mediated insulin resistance and inhibits insulin-induced adipogenesis in fetal brown adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15365619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-004-1503-7

1 reference

Europe PubMed Central

PubMed publication ID

9 December 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 December 2017

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