Alpha-adrenergic inhibition of proliferation in HepG2 cells stably transfected with the alpha1B-adrenergic receptor through a p42MAPkinase/p21Cip1/WAF1-dependent pathway (Q45114100)

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scientific article published in September 1998

Language	Label	Description	Also known as
English	Alpha-adrenergic inhibition of proliferation in HepG2 cells stably transfected with the alpha1B-adrenergic receptor through a p42MAPkinase/p21Cip1/WAF1-dependent pathway	scientific article published in September 1998

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scholarly article

1 reference

Europe PubMed Central

9 December 2017

Alpha-adrenergic inhibition of proliferation in HepG2 cells stably transfected with the alpha1B-adrenergic receptor through a p42MAPkinase/p21Cip1/WAF1-dependent pathway (English)

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Europe PubMed Central

9 December 2017

author name string

K L Auer

1

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M S Spector

2

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R M Tombes

3

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Europe PubMed Central

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P Seth

4

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Europe PubMed Central

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P B Fisher

5

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B Gao

6

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Europe PubMed Central

9 December 2017

P Dent

7

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Europe PubMed Central

9 December 2017

G Kunos

8

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language of work or name

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publication date

1 September 1998

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Europe PubMed Central

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436

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1

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131-138

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9 December 2017

alpha 1-adrenergic receptor subtypes. Molecular structure, function, and signaling

1 reference

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Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase

1 reference

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Differential regulation of the mitogen-activated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes

1 reference

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Inverse regulation of hepatic alpha 1B- and beta 2-adrenergic receptors. Cellular mechanisms and physiological implications

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Norepinephrine and epidermal growth factor: dynamics of their interaction in the stimulation of hepatocyte DNA synthesis

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G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity

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Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase

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Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1 reference

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Adrenergic regulation of glycogenolysis in rat liver after cholestasis. Modulation of the balance between alpha 1 and beta 2 receptors

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Transcriptional regulation of alpha(1b) adrenergic receptors (alpha(1b)AR) by nuclear factor 1 (NF1): a decline in the concentration of NF1 correlates with the downregulation of alpha(1b)AR gene expression in regenerating liver

1 reference

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Steady state levels of hepatic alpha 1- and beta 2-adrenergic receptors and gene transcripts during development of the male rat.

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Changes in alpha-1 and beta-2 adrenoceptor density in human hepatocellular carcinoma

1 reference

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Patterns of alpha-1-adrenergic receptor expression in regenerating and neoplastic hepatic tissue

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Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells

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The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic.

1 reference

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Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro

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The rat alpha 1B adrenergic receptor gene middle promoter contains multiple binding sites for sequence-specific proteins including a novel ubiquitous transcription factor

1 reference

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Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

1 reference

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Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase

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Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

1 reference

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Principles of CDK regulation

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Inhibitors of mammalian G1 cyclin-dependent kinases

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Cdc2 regulatory factors

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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1 reference

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Inhibition of cyclin-dependent kinases by p21

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CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice

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Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21WAF1/CIP1 via C/EBPbeta

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MyoD-induced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation

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Cooperating oncogenes converge to regulate cyclin/cdk complexes.

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Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

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Signal transduction pathways involving the Raf proto-oncogene

1 reference

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Alpha1-adrenergic receptor signaling via Gh is subtype specific and independent of its transglutaminase activity

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7 January 2021

Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation

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Induction of DNA synthesis in cultured rat hepatocytes through stimulation of alpha 1 adrenoreceptor by norepinephrine

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Reciprocal Expressions of α1- and β-Adrenergic Receptors, but Constant Expression of Glucagon Receptor by Rat Hepatocytes during Development and Primary Culture1

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Rapid inverse changes in alpha 1B- and beta 2-adrenergic receptors and gene transcripts in acutely isolated rat liver cells

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p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage

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Nerve growth factor induces transcription of the p21 WAF1/CIP1 and cyclin D1 genes in PC12 cells by activating the Sp1 transcription factor

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Induction of c-myc transcription by the v-Abl tyrosine kinase requires Ras, Raf1, and cyclin-dependent kinases

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Antisense oligonucleotide of WAF1 gene prevents EGF-induced cell-cycle arrest in A431 cells

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Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control

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7 January 2021

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10.1016/S0014-5793(98)01074-6

1 reference

Europe PubMed Central

9 December 2017

1 reference

Europe PubMed Central

9 December 2017

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