Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles (Q45193717)

10 December 2017

Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles (English)

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10 December 2017

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Dominique Lison

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author name string

Virginie Barbarin

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10 December 2017

Zhou Xing

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10 December 2017

Monique Delos

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Francois Huaux

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10 December 2017

language of work or name

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17 December 2004

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American Journal of Physiology - Lung Cellular and Molecular Physiology

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10 December 2017

288

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L841-8

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Introduction of the interleukin-10 gene into mice inhibited bleomycin-induced lung injury in vivo

10 December 2017

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Characterization of the effect of interleukin-10 on silica-induced lung fibrosis in mice

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Macrophage deactivation by interleukin 10

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Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis

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Attenuation of lung inflammation and fibrosis in interferon-gamma-deficient mice after intratracheal bleomycin

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Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes

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Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones

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Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice

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Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin-mouse model of lung fibrosis: downregulation of TGF-beta and procollagen I and III gene expression

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Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung

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Pulmonary tuberculosis in BALB/c mice with non-functional IL-4 genes: changes in the inflammatory effects of TNF-alpha and in the regulation of fibrosis

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A profibrotic function of IL-12p40 in experimental pulmonary fibrosis

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Lung Fibrosis Induced by Silica Particles in NMRI Mice Is Associated with an Upregulation of the p40 Subunit of Interleukin-12 and Th-2 Manifestations

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Dual roles of IL-4 in lung injury and fibrosis

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Eosinophils and T lymphocytes possess distinct roles in bleomycin-induced lung injury and fibrosis

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Role of Interleukin-10 in the Lung Response to Silica in Mice

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Transforming growth factor-beta (TGF-beta) in silicosis

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IL-12 attenuates bleomycin-induced pulmonary fibrosis

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Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice

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Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis

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Fibroblast prostaglandin E2 synthesis. Persistence of an abnormal phenotype after short-term exposure to mononuclear cell products

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Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways.

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Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1).

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Re-emergence of an "orphan" test for pulmonary embolism.

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Use of tetrandrine to differentiate between mechanisms involved in silica-versus bleomycin-induced fibrosis

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IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization

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Human alveolar macrophage cytokine release in response to in vitro and in vivo asbestos exposure

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Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4

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Potential Action of IL-4 and IL-13 as Fibrogenic Factors on Lung Fibroblasts in vitro

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Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy

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Regulation of chemokine expression by IL-10 in lung inflammation

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Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung

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Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness

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Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

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Adenoviral vector-mediated interleukin-10 expression in vivo: intramuscular gene transfer inhibits cytokine responses in endotoxemia

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Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

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Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice.

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An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection

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10.1152/AJPLUNG.00329.2004

21 January 2018

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10 December 2017

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