Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway (Q45251821)

11 December 2017

Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway (English)

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11 December 2017

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M Ueno

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11 December 2017

J B C Carvalheira

2

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R C Tambascia

3

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R M N Bezerra

4

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M E Amaral

5

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E M Carneiro

6

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F Folli

7

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K G Franchini

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M J A Saad

9

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4 February 2005

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48

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3

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506-518

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https://scigraph.springernature.com/pub.10.1007/s00125-004-1662-6

11 December 2017

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12 December 2020

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12 December 2020

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Hyperinsulinemia increases the amount of GLUT4 mRNA in white adipose tissue and decreases that of muscles: a clue for increased fat depot and insulin resistance.

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A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

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12 December 2020

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

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Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.

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12 December 2020

10.1007/S00125-004-1662-6

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DOI

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11 December 2017

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