The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats. (Q45270557)

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English	The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats.	scientific article

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8 January 2020

The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats (English)

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8 January 2020

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8 January 2020

author name string

Jason P Schroeder

1

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8 January 2020

David H Overstreet

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8 January 2020

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17 February 2005

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8 January 2020

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9

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Psychopharmacology

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179

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8 January 2020

1

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8 January 2020

262-270

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8 January 2020

https://scigraph.springernature.com/pub.10.1007/s00213-005-2175-9

0 references

Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus

1 reference

https://api.crossref.org/works/10.1007%2FS00213-005-2175-9

21 January 2018

Effect of dopamine agonists and antagonists on ethanol-reinforced behavior: the involvement of the nucleus accumbens.

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https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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Development of an alcohol-deprivation effect in rats

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https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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Pharmacological and anatomical evidence for an interaction between mGluR5- and GABA(A) alpha1-containing receptors in the discriminative stimulus effects of ethanol.

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https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination

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https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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Rodent lines selected for factors affecting alcohol consumption.

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https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders

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https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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Ventral tegmental microinjections of quinpirole decrease ethanol and sucrose-reinforced responding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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Metabotropic glutamate receptor agonists alter neuronal excitability and Ca2+ levels via the phospholipase C transduction pathway in cultured Purkinje neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Role of polyamines and NMDA receptors in ethanol dependence and withdrawal.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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Chronic ethanol treatment and withdrawal alter ACPD-evoked calcium signals in developing Purkinje neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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Drug addiction, dysregulation of reward, and allostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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Ionotropic glutamate receptors as sites of action for ethanol in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Ethanol, sedative hypnotics, and glutamate receptor function in brain and cultured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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The alcohol deprivation effect in the alcohol-preferring P rat under free-drinking and operant access conditions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Regulation by metabotropic glutamate receptor 5 of LTP in the dentate gyrus of freely moving rats: relevance for learning and memory formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Effects of intraaccumbens injections of dopamine agonists and antagonists on sucrose and sucrose-ethanol reinforced responding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Effects of a novel uncompetitive NMDA receptor antagonist, MRZ 2/579 on ethanol self-administration and ethanol withdrawal seizures in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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Initiation of ethanol reinforcement using a sucrose-substitution procedure in food- and water-sated rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Recent animal models of alcoholism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Effects of ventral tegmental microinjections of the GABAA agonist muscimol on self-administration of ethanol and sucrose.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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Reduced stress-induced hyperthermia in mGluR5 knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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mGlu5 receptor antagonists: a novel class of anxiolytics?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Ethanol action on excitatory amino acid activated ion channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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Co-stimulation of mGluR5 and N-Methyl-D-aspartate Receptors Is Required for Potentiation of Excitatory Synaptic Transmission in Hippocampal Neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Chronic ethanol on mRNA levels of IP3R1, IP3 3-kinase and mGluR1 in mouse Purkinje neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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Group I metabotropic glutamate receptors: implications for brain diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

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Aspartate and glutamate transport in acutely and chronically ethanol exposed neonatal rat primary astrocyte cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Anxiolytic-like activity of the mGluR5 antagonist MPEP: a comparison with diazepam and buspirone

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses

1 reference

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12 December 2020

based on heuristic

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The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Effects of ethanol on stimulated inositol phospholipid hydrolysis in rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Long and short alcohol deprivation: effects on AA and P alcohol-preferring rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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A review of the effects of prenatal or early postnatal ethanol exposure on brain ligand-gated ion channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alcohol exposure during brain development reduces 3H-MK-801 binding and enhances metabotropic-glutamate receptor-stimulated phosphoinositide hydrolysis in rat hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alcohol self-administration: further examination of the role of dopamine receptors in the nucleus accumbens.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabotropic glutamate receptors: structure and functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute ethanol alters calcium signals elicited by glutamate receptor agonists and K+ depolarization in cultured cerebellar Purkinje neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of repeated alcohol deprivations on operant ethanol self-administration by alcohol-preferring (P) rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute effects of ethanol on GABAA and glycine receptor function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mGlu5 receptor agonist CHPG stimulates striatal glutamate release: possible involvement of A2A receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prenatal ethanol exposure enhances glutamate release stimulated by quisqualate in rat cerebellar granule cell cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Second messenger pathways involved in up-regulation of an L-type calcium channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate-mediated transmission, alcohol, and alcoholism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Naltrexone in the treatment of alcohol dependence

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

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LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel uncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist MRZ 2/579 suppresses ethanol intake in long-term ethanol-experienced rats and generalizes to ethanol cue in drug discrimination procedure.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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