A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease (Q45291617)

11 December 2017

A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease (English)

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11 December 2017

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5

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11 December 2017

Han-Yun Hsiao

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11 December 2017

Yu-Chen Chen

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2

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11 December 2017

Hui-Mei Chen

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3

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11 December 2017

Pang-Hsien Tu

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11 December 2017

30 January 2013

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11 December 2017

Human Molecular Genetics

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11 December 2017

22

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11 December 2017

9

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11 December 2017

1826-1842

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Huntingtin-protein interactions and the pathogenesis of Huntington's disease

11 December 2017

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Transcriptional abnormalities in Huntington disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Polyglutamine diseases and transport problems: deadly traffic jams on neuronal highways.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Inclusion formation in Huntington's disease R6/2 mouse muscle cultures

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Reactive astrocytes: cellular and molecular cues to biological function

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

The role of glial cells in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Therapeutic approaches to inflammation in neurodegenerative disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Microglial activation correlates with severity in Huntington disease: a clinical and PET study.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: a multimodal imaging study

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

A sensitive and selective assay of neuronal degeneration in cell culture.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Neuroinflammation in Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Distinct neuroinflammatory profile in post-mortem human Huntington's disease.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Local neuroinflammation and the progression of Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Novel anti-inflammatory therapy for Parkinson's disease.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Activation of AMP-activated protein kinase by kainic acid mediates brain-derived neurotrophic factor expression through a NF-kappaB dependent mechanism in C6 glioma cells

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Endotoxin preconditioning prevents cellular inflammatory response during ischemic neuroprotection in mice

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Quantitative Limulus lysate assay for endotoxin and the effect of plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Neurological abnormalities in a knock-in mouse model of Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Assessment of motor balance and coordination in mice using the balance beam

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

Assessment of spatial memory.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

TNF-alpha/IFN-gamma-induced iNOS expression increased by prostaglandin E2 in rat primary astrocytes via EP2-evoked cAMP/PKA and intracellular calcium signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

cAMP-response element-binding protein contributes to suppression of the A2A adenosine receptor promoter by mutant Huntingtin with expanded polyglutamine residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT036

21 January 2018

Identifiers

DOI

10.1093/HMG/DDT036

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11 December 2017

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