AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: interference with the Akt/NF-kappaB survival pathway. (Q45296438)

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scientific article published in April 2005

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English	AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: interference with the Akt/NF-kappaB survival pathway.	scientific article published in April 2005

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scholarly article

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9 January 2020

AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: interference with the Akt/NF-kappaB survival pathway (English)

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9 January 2020

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Serratia marcescens

object named as

Serratia marcescens

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Vanessa Soto-Cerrato

5

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9 January 2020

Ricardo Pérez-Tomás

9

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9 January 2020

Angeles Garcia Pardo

10

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9 January 2020

Beatriz Montaner

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9 January 2020

Ernest Giralt i Lledó

7

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9 January 2020

author name string

Escobar-Díaz E

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9 January 2020

López-Martín EM

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9 January 2020

Hernández del Cerro M

3

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9 January 2020

Puig-Kroger A

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9 January 2020

García-Marco JA

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9 January 2020

publication date

1 April 2005

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9 January 2020

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9 January 2020

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9 January 2020

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9 January 2020

572-579

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9 January 2020

https://scigraph.springernature.com/pub.10.1038/sj.leu.2403679

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The pathology of the chronic lymphoid leukaemias

1 reference

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21 January 2018

Update on the biology of chronic lymphocytic leukemia

1 reference

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Role of apoptosis in the pathogenesis of B-cell chronic lymphocytic leukaemia

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Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells.

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21 January 2018

Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta.

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A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells.

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Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance

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New Directions in the Diagnosis and Treatment of Chronic Lymphocytic Leukaemia

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Recent developments in depsipeptide research

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Analysis of histone deacetylase inhibitor, depsipeptide (FR901228), effect on multiple myeloma

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Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein

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Increased cell surface hydrophobicity of a Serratia marcescens NS 38 mutant lacking wetting activity

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Caspases: the executioners of apoptosis

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Induction of NF-kappaB by the Akt/PKB kinase

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Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

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Involvement of p53 in alpha4beta1 integrin-mediated resistance of B-CLL cells to fludarabine.

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21 January 2018

Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation

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PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A.

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Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes

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The histone deacetylase inhibitor MS-275 induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia cells

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21 January 2018

Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis

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The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

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Differential modulation of signaling pathways and apoptosis of ras-transformed 10T1/2 cells by the depsipeptide FR901228.

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Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery.

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Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells.

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The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change

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The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria

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Targeting cell cycle and apoptosis for the treatment of human malignancies

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Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells

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7 January 2021

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Inhibition of NF-kappaB activity and enhancement of apoptosis by the neuropeptide calcitonin gene-related peptide

1 reference

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7 January 2021

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Induction of caspase-dependent programmed cell death in B-cell chronic lymphocytic leukemia by anti-CD22 immunotoxins

1 reference

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10.1038/SJ.LEU.2403679

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9 January 2020

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9 January 2020

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