Mutant huntingtin is present in neuronal grafts in Huntington disease patients (Q45299114)

11 December 2017

Mutant huntingtin is present in neuronal grafts in Huntington disease patients (English)

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11 December 2017

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11 December 2017

Isabelle St-Amour

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Diego Mantovani

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Diego Mantovani

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Giulia Cisbani

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Giulia Cisbani

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Robert A Hauser

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Robert A Hauser

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Roger A Barker

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11 December 2017

Francesca Cicchetti

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author name string

Nicolas Vallières

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11 December 2017

Martine Saint-Pierre

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Ranna Tolouei

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Jeremy N Skepper

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Thomas B Freeman

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6 June 2014

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76

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31-42

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The current clinical management of Huntington's disease

11 December 2017

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Molecular mechanisms and potential therapeutical targets in Huntington's disease

21 January 2018

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The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

21 January 2018

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Huntington's disease: from molecular pathogenesis to clinical treatment

21 January 2018

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Technical factors that influence neural transplant safety in Huntington's disease.

21 January 2018

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Rationale for intrastriatal grafting of striatal neuroblasts in patients with Huntington's disease

21 January 2018

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Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum

21 January 2018

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Anatomy and connectivity of intrastriatal striatal transplants

21 January 2018

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Afferent and efferent connections of striatal grafts implanted into the ibotenic acid lesioned neostriatum in adult rats.

21 January 2018

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Reversal of long-term locomotor abnormalities in the kainic acid model of huntington's disease by day 18 fetal striatal implants

21 January 2018

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Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology

21 January 2018

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Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration

21 January 2018

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Striatal allografts in patients with Huntington's disease: impact of diminished astrocytes and vascularization on graft viability.

21 January 2018

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Bilateral human fetal striatal transplantation in Huntington's disease.

21 January 2018

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System-wide immunohistochemical analysis of protein co-localization

21 January 2018

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SIMPLE: a sequential immunoperoxidase labeling and erasing method

21 January 2018

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Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length

21 January 2018

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Antibody elution method for multiple immunohistochemistry on primary antibodies raised in the same species and of the same subtype

21 January 2018

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Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression

21 January 2018

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Simultaneous electrophoretic analysis of proteins of very high and low molecular mass using Tris-acetate polyacrylamide gels.

21 January 2018

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Structure of inclusions of Huntington's disease brain revealed by synchrotron infrared microspectroscopy: polymorphism and relevance to cytotoxicity

21 January 2018

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Molecular origin of polyglutamine aggregation in neurodegenerative diseases

21 January 2018

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

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Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

21 January 2018

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

21 January 2018

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Prion-like transmission of protein aggregates in neurodegenerative diseases

21 January 2018

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Transmissible proteins: expanding the prion heresy

21 January 2018

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100 years of Lewy pathology.

21 January 2018

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Is Parkinson's disease a prion disorder?

21 January 2018

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Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

21 January 2018

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

21 January 2018

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Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

21 January 2018

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Propagation of tau pathology in a model of early Alzheimer's disease

21 January 2018

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Brain homogenates from human tauopathies induce tau inclusions in mouse brain

21 January 2018

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Trans-synaptic spread of tau pathology in vivo

21 January 2018

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Neuronal degeneration in striatal transplants and Huntington's disease: potential mechanisms and clinical implications.

21 January 2018

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Extracellular amyloid formation and associated pathology in neural grafts.

21 January 2018

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Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

21 January 2018

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The fate of cell grafts for the treatment of Huntington's disease: the post-mortem evidence.

21 January 2018

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Neuropathology in transplants in Parkinson's disease: implications for disease pathogenesis and the future of cell therapy

21 January 2018

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Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain

21 January 2018

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Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis

21 January 2018

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Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington's disease

21 January 2018

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Bone marrow transplantation confers modest benefits in mouse models of Huntington's disease

21 January 2018

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Neural transplantation in Huntington disease: long-term grafts in two patients

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANA.24174

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11 December 2017

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