A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. (Q45306622)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17921520%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

title

A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17921520%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

0 references

0 references

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17921520%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Sovan Sarkar

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17921520%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

author name string

Gauri Krishna

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17921520%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Sara Imarisio

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17921520%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Shinji Saiki

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17921520%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

David C Rubinsztein

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17921520%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

publication date

6 October 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17921520%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

published in

Human Molecular Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17921520%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

volume

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17921520%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17921520%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

page(s)

170-178

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17921520%20AND%20SRC:MED&resulttype=core&format=json

Lessons from animal models of Huntington's disease

8 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Opinion: What is the role of protein aggregation in neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Potential therapeutic applications of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Rapamycin alleviates toxicity of different aggregate-prone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington's disease gene carriers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Lithium induces autophagy by inhibiting inositol monophosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Molecular targets of lithium action

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Methods for monitoring autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Drosophila in the study of neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington's disease mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

A molecular investigation of true dominance in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294

How to interpret LC3 immunoblotting

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM294