Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function (Q45345758)

13 December 2017

Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function (English)

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13 December 2017

Ian R Watson

1

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13 December 2017

Alvaro Blanch

2

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13 December 2017

Dan C C Lin

3

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13 December 2017

Michael Ohh

4

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13 December 2017

Meredith S Irwin

5

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13 December 2017

language of work or name

English

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publication date

14 September 2006

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Journal of Biological Chemistry

13 December 2017

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13 December 2017

281

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13 December 2017

45

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13 December 2017

34096-34103

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p73 is a simian [correction of human] p53-related protein that can induce apoptosis

13 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Viral oncoproteins discriminate between p53 and the p53 homolog p73.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

p73: regulator in cancer and neural development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Transdominant DeltaTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

DeltaTAp73 upregulation correlates with poor prognosis in human tumors: putative in vivo network involving p73 isoforms, p53, and E2F-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

DeltaN-p73alpha accumulates in human neuroblastic tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Aberrant expression of DeltaNp73 in benign and malignant tumours of the prostate: correlation with Gleason score

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Clinical relevance of dominant-negative p73 isoforms for responsiveness to chemotherapy and survival in ovarian cancer: evidence for a crucial p53-p73 cross-talk in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Nedd8 on cullin: building an expressway to protein destruction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

RETRACTED: p73alpha regulation by Chk1 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

The ubiquitin-protein ligase Itch regulates p73 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Mdm2 binds p73 alpha without targeting degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

MDM2 and MDMX bind and stabilize the p53-related protein p73

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

MDM2 suppresses p73 function without promoting p73 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Nuclear import and export signals in control of the p53-related protein p73.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

C-terminal ubiquitination of p53 contributes to nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Isolation by a replica-plating technique of Chinese hamster temperature-sensitive cell cycle mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Two new p73 splice variants, gamma and delta, with different transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Molecular characterization of the hdm2-p53 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Regulation of the p73 protein stability and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

Ubiquitin-dependent degradation of p73 is inhibited by PML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

MDM2 and MDMX can interact differently with ARF and members of the p53 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603654200

21 January 2018

Identifiers

DOI

10.1074/JBC.M603654200

1 reference

13 December 2017

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