The design of optimal therapeutic small interfering RNA molecules targeting diverse strains of influenza A virus (Q45362584)

13 December 2017

The design of optimal therapeutic small interfering RNA molecules targeting diverse strains of influenza A virus (English)

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13 December 2017

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9

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13 December 2017

Nafisa Hassan

2

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Giulia Marsili

object named as

Giulia Marsili

8

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Anna Lisa Remoli

object named as

Anna Lisa Remoli

5

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Mahmoud ElHefnawi

object named as

Mahmoud ElHefnawi

1

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author name string

Mona Kamar

3

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13 December 2017

Rania Siam

4

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13 December 2017

Iman El-Azab

6

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13 December 2017

Osama AlAidy

7

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13 December 2017

language of work or name

English

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publication date

11 October 2011

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13 December 2017

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13 December 2017

27

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13 December 2017

3364-3370

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13 December 2017

24

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An algorithm for selection of functional siRNA sequences.

13 December 2017

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https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus.

21 January 2018

1 reference

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3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

21 January 2018

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RNAi for treating hepatitis B viral infection

21 January 2018

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Sfold web server for statistical folding and rational design of nucleic acids

21 January 2018

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https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Identification of novel conserved functional motifs across most Influenza A viral strains

21 January 2018

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https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Impact of target mRNA structure on siRNA silencing efficiency: A large-scale study

21 January 2018

1 reference

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Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Designing optimal siRNA based on target site accessibility.

21 January 2018

1 reference

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A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

21 January 2018

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https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Design of a genome-wide siRNA library using an artificial neural network

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

RNA interference: a potent tool for gene-specific therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

21 January 2018

1 reference

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Strategies for silencing human disease using RNA interference

21 January 2018

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Approximate Bayesian feature selection on a large meta-dataset offers novel insights on factors that effect siRNA potency

21 January 2018

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https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Efficient siRNA selection using hybridization thermodynamics

21 January 2018

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https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Comparison of approaches for rational siRNA design leading to a new efficient and transparent method

21 January 2018

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https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Thermodynamics of RNA-RNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Optimal design and validation of antiviral siRNA for targeting HIV-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

siVirus: web-based antiviral siRNA design software for highly divergent viral sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

In silico selection of active siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Design of siRNAs producing unstructured guide-RNAs results in improved RNA interference efficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Rational siRNA design for RNA interference

21 January 2018

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https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

siRecords: an extensive database of mammalian siRNAs with efficacy ratings.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Computational models with thermodynamic and composition features improve siRNA design

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

21 January 2018

1 reference

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Closed chromatin architecture is induced by an RNA duplex targeting the HIV-1 promoter region

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

The impact of target site accessibility on the design of effective siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

A status report on RNAi therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat.

21 January 2018

1 reference

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Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference

21 January 2018

1 reference

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An accurate and interpretable model for siRNA efficacy prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Filtering of ineffective siRNAs and improved siRNA design tool.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

Effective small interfering RNAs targeting matrix and nucleocapsid protein gene inhibit influenza A virus replication in cells and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

RNA interference of avian influenza virus H5N1 by inhibiting viral mRNA with siRNA expression plasmids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

A potential treatment for pandemic influenza using siRNAs targeting conserved regions of influenza A

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTR555

10.1093/BIOINFORMATICS/BTR555

21 January 2018

Identifiers

DOI

1 reference

journals/bioinformatics/ElHefnawiHKSREAMS11

13 December 2017

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DBLP Dataset 2021-01-02

28 January 2021

1 reference