Human immunodeficiency virus-1/surface glycoprotein 120 induces apoptosis through RNA-activated protein kinase signaling in neurons. (Q45399758)

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8 January 2020

title

Human immunodeficiency virus-1/surface glycoprotein 120 induces apoptosis through RNA-activated protein kinase signaling in neurons (English)

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9

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Bryan Williams

series ordinal

6

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5

Eliezer Masliah

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2

Debbie D Watry

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3

Claudia F Flynn

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7

Marcus Kaul

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8

Stuart A Lipton

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author name string

Mehrdad Alirezaei

series ordinal

1

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William B Kiosses

series ordinal

4

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language of work or name

English

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publication date

1 October 2007

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8 January 2020

published in

Journal of Neuroscience

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volume

27

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issue

41

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page(s)

11047-11055

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describes a project that uses

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ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

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PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.

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Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease.

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Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord

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The chemokine receptor CXCR4 regulates cell-cycle proteins in neurons.

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Protein kinase inhibitor 2-aminopurine overrides multiple genotoxic stress-induced cellular pathways to promote cell survival

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Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice

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An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease

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Blockade of NMDA receptor-mediated mobilization of intracellular Ca2+ prevents neurotoxicity

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PKR activation in neurodegenerative disease

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The N-terminus of PKR is responsible for the activation of the NF-kappaB signaling pathway by interacting with the IKK complex

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Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis

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S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

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Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity.

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HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection.

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Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation

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Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stress

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HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons

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Intracerebral injection of human immunodeficiency virus type 1 coat protein gp120 differentially affects the expression of nerve growth factor and nitric oxide synthase in the hippocampus of rat.

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12 December 2020

An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells

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12 December 2020

Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase

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12 December 2020

PACT, a protein activator of the interferon-induced protein kinase, PKR.

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12 December 2020

Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity

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12 December 2020

Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling

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12 December 2020

10.1523/JNEUROSCI.2733-07.2007

Identifiers

DOI

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