Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation (Q80149163)

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scientific article published on 21 August 2006

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English	Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation	scientific article published on 21 August 2006

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29 December 2019

Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation (English)

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29 December 2019

author name string

Takada Y

1

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29 December 2019

Ichikawa H

2

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29 December 2019

Pataer A

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29 December 2019

Swisher S

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29 December 2019

Aggarwal BB

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21 August 2006

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1201-1212

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29 December 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209906

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PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.

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RNA-dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a STAT1-independent pathway.

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Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex.

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TRAF family proteins link PKR with NF-kappa B activation

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The catalytic activity of dsRNA-dependent protein kinase, PKR, is required for NF-kappaB activation.

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Activation of the I kappa B alpha kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase PKR.

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