Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness (Q45736205)

15 December 2017

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness (English)

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15 December 2017

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Shinya Yamanaka

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Hiroyuki Hioki

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William L. Klein

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William L Klein

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Kazutoshi Takahashi

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Naohiro Egawa

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Satoko Yamawaki

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Motoko Naitoh

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Keisuke Okita

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Kayoko Tsukita

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Takayuki Kondo

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Masashi Asai

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Yutaka Ohsawa

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Yoshihide Sunada

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Keiko Imamura

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Naoki Yahata

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Isao Asaka

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Takashi Aoi

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Akira Watanabe

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Kaori Watanabe

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Chie Kadoya

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Rie Nakano

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Dai Watanabe

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Kei Maruyama

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Osamu Hori

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Satoshi Hibino

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Tominari Choshi

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Tatsutoshi Nakahata

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Takeshi Kaneko

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Katsuhiro Yoshikawa

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Shigehiko Suzuki

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Ryuji Hata

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Shu-Ichi Ueno

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Tsuneyoshi Seki

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Kazuhiro Kobayashi

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Tatsushi Toda

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Kazuma Murakami

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Hiroshi Mori

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Takashi Asada

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Ryosuke Takahashi

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Nobuhisa Iwata

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Haruhisa Inoue

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15 December 2017

language of work or name

English

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publication date

21 February 2013

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487-496

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describes a project that uses

15 December 2017

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A more efficient method to generate integration-free human iPS cells

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24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/NMETH.1591

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/NATURE10821

Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Amyloid &#946;-Peptide [1-42]-Associated Free Radical-Induced Oxidative Stress And Neurodegeneration in Alzheimers Disease Brain: Mechanisms and Consequences

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Monoclonal antibodies that target pathological assemblies of Abeta.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

ADDLs and the signaling web that leads to Alzheimer's disease

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

A dibenzoylmethane derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum stress

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Modeling familial Alzheimer's disease with induced pluripotent stem cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Specification of transplantable astroglial subtypes from human pluripotent stem cells

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Effect of pathogenic mutations on the structure and dynamics of Alzheimer's A beta 42-amyloid oligomers.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

A specific amyloid-beta protein assembly in the brain impairs memory

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Small-molecule inhibitors of bone morphogenic protein and activin/nodal signals promote highly efficient neural induction from human pluripotent stem cells.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Docosahexaenoic acid protects from amyloid and dendritic pathology in an Alzheimer's disease mouse model

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Implication of the small GTPase Rac1 in the generation of reactive oxygen species in response to beta-amyloid in C6 astroglioma cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Clinical course of patients with familial early-onset Alzheimer's disease potentially lacking senile plaques bearing the E693Δ mutation in amyloid precursor protein.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Neurodegenerative diseases and oxidative stress

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.STEM.2013.01.009

Identifiers

DOI

10.1016/J.STEM.2013.01.009

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15 December 2017

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