Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness (Q45736205)

15 December 2017

title

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness (English)

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Shinya Yamanaka

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Hiroyuki Hioki

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William L. Klein

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object named as

William L Klein

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Kazutoshi Takahashi

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Naohiro Egawa

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Satoko Yamawaki

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Motoko Naitoh

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Keisuke Okita

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Kayoko Tsukita

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Takayuki Kondo

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Masashi Asai

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Yumiko Kutoku

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Yutaka Ohsawa

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Yoshihide Sunada

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Keiko Imamura

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Naoki Yahata

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Isao Asaka

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Takashi Aoi

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Akira Watanabe

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Kaori Watanabe

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Chie Kadoya

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Rie Nakano

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Dai Watanabe

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Kei Maruyama

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Osamu Hori

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Satoshi Hibino

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Tominari Choshi

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Tatsutoshi Nakahata

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Takeshi Kaneko

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Katsuhiro Yoshikawa

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Shigehiko Suzuki

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Ryuji Hata

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Shu-Ichi Ueno

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Tsuneyoshi Seki

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Kazuhiro Kobayashi

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Tatsushi Toda

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Kazuma Murakami

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Hiroshi Mori

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Takashi Asada

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Ryosuke Takahashi

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Nobuhisa Iwata

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Haruhisa Inoue

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language of work or name

English

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publication date

21 February 2013

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15 December 2017

volume

12

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issue

4

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page(s)

487-496

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describes a project that uses

15 December 2017

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Effect of pathogenic mutations on the structure and dynamics of Alzheimer's A beta 42-amyloid oligomers.

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DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia

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A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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A specific amyloid-beta protein assembly in the brain impairs memory

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Small-molecule inhibitors of bone morphogenic protein and activin/nodal signals promote highly efficient neural induction from human pluripotent stem cells.

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

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Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains

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Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

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Docosahexaenoic acid protects from amyloid and dendritic pathology in an Alzheimer's disease mouse model

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Neurodegenerative diseases and oxidative stress

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Identifiers

DOI

10.1016/J.STEM.2013.01.009

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15 December 2017

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