The FOXP3+ subset of human CD4+CD8+ thymocytes is immature and subject to intrathymic selection (Q45767215)

15 December 2017

title

The FOXP3+ subset of human CD4+CD8+ thymocytes is immature and subject to intrathymic selection (English)

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15 December 2017

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Heli Tuovinen

1

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15 December 2017

Pirkka T Pekkarinen

2

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15 December 2017

Laura H Rossi

3

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15 December 2017

Ilkka Mattila

4

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15 December 2017

T Petteri Arstila

5

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15 December 2017

publication date

27 May 2008

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15 December 2017

Immunology & Cell Biology

published in

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15 December 2017

volume

86

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15 December 2017

issue

6

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15 December 2017

page(s)

523-529

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15 December 2017

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

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Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

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The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.

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Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

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Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

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Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function

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Regulatory T cell lineage specification by the forkhead transcription factor foxp3

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An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

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Developmental regulation of Foxp3 expression during ontogeny.

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Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter

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Regulatory T cell development in the absence of functional Foxp3.

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Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes

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Development and activation of regulatory T cells in the human fetus.

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Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro

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CD4+ CD25+ FOXP3+ regulatory T cells from human thymus and cord blood suppress antigen-specific T cell responses.

21 January 2018

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Functional features of human CD25+ regulatory thymocytes

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Development of alphabeta T cells in the human thymus

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Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells

21 January 2018

1 reference

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Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

21 January 2018

1 reference

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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

21 January 2018

1 reference

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Induction of thymocyte positive selection does not convey immediate resistance to negative selection.

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CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

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T-cell repertoire diversity and clonal expansions in normal and clinical samples

21 January 2018

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Human CD4+CD25+ regulatory T cells share equally complex and comparable repertoires with CD4+CD25- counterparts

21 January 2018

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Thymic development and peripheral homeostasis of regulatory T cells.

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Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

21 January 2018

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Delayed functional maturation of natural regulatory T cells in the medulla of postnatal thymus: role of TSLP.

21 January 2018

1 reference

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MHC class II-independent CD25+ CD4+ CD8alpha beta+ alpha beta T cells attenuate CD4+ T cell-induced transfer colitis

21 January 2018

1 reference

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Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2008.36

Ontogeny of CD4+CD25+ regulatory/suppressor T cells in human fetuses

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2008.36

Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2008.36

Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells

21 January 2018

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Foxp3-dependent programme of regulatory T-cell differentiation

21 January 2018

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Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level

21 January 2018

1 reference

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7 January 2021

Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors

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https://api.crossref.org/works/10.1038%2FICB.2008.36

7 January 2021

Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells

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https://api.crossref.org/works/10.1038%2FICB.2008.36

7 January 2021

Cutting edge: human CD4-CD8- thymocytes express FOXP3 in the absence of a TCR

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https://api.crossref.org/works/10.1038%2FICB.2008.36

7 January 2021

CD4+CD25high regulatory cells in human peripheral blood

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https://api.crossref.org/works/10.1038%2FICB.2008.36

7 January 2021

Identifiers

DOI

10.1038/ICB.2008.36

1 reference

15 December 2017

Dimensions Publication ID

1033631229

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1 reference

15 December 2017