A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. (Q36078042)

12 August 2017

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title

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. (English)

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12 August 2017

Jason D Fontenot

1

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12 August 2017

Alexander Y Rudensky

series ordinal

2

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12 August 2017

language of work or name

English

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publication date

1 April 2005

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12 August 2017

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12 August 2017

6

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12 August 2017

331-337

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12 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/ni1179

12 August 2017

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cites work

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7 January 2021

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Do suppressor T cells exist?

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Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

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Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

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Regulatory T cells in autoimmmunity*.

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The third function of the thymus.

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CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

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Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

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Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state.

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Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo

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7 January 2021

In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro

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7 January 2021

Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo

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7 January 2021

CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10

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7 January 2021

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2

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7 January 2021

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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7 January 2021

In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

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7 January 2021

Mechanisms of suppression by suppressor T cells

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7 January 2021

CD4+ CD25+ suppressor T cells: more questions than answers

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7 January 2021

CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes

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7 January 2021

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

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7 January 2021

Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease

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7 January 2021

CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness

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7 January 2021

Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function

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7 January 2021

Human T regulatory cells can use the perforin pathway to cause autologous target cell death

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7 January 2021

T cell regulation as a side effect of homeostasis and competition

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7 January 2021

Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals

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7 January 2021

Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function.

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7 January 2021

Interleukin-2 is essential for CD4+CD25+ regulatory T cell function

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7 January 2021

CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion

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7 January 2021

CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations.

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Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency.

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Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

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Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

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Regulatory potential and control of Foxp3 expression in newborn CD4+ T cells

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Selecting and maintaining a diverse T-cell repertoire

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7 January 2021

Development and function of CD25+CD4+ regulatory T cells

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The role of TCR specificity in naturally arising CD25+ CD4+ regulatory T cell biology

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High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

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7 January 2021

Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis

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Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression

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7 January 2021

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

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7 January 2021

Origin of regulatory T cells with known specificity for antigen

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CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor

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7 January 2021

Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation

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7 January 2021

Mature T cells depend on signaling through the IKK complex.

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7 January 2021

Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors

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7 January 2021

Lck activity controls CD4/CD8 T cell lineage commitment.

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7 January 2021

Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells

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7 January 2021

Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells.

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7 January 2021

Self-specific MHC class II-restricted CD4-CD8- T cells that escape deletion and lack regulatory activity

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7 January 2021

Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype

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7 January 2021

Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epithelium

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7 January 2021

Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells

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7 January 2021

Peptide specificity of thymic selection of CD4+CD25+ T cells.

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7 January 2021

Self-representation in the thymus: an extended view

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7 January 2021

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

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7 January 2021

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

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7 January 2021

Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

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7 January 2021

Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10.

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7 January 2021

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

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7 January 2021

Acquisition of anergic and suppressive activities in transforming growth factor-beta-costimulated CD4+CD25- T cells.

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7 January 2021

TGF regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo

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7 January 2021

Cutting Edge: TGF- Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T Cells

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7 January 2021

Tolerance, not immunity, crucially depends on IL-2.

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7 January 2021

Interleukin 2 signaling is required for CD4(+) regulatory T cell function

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7 January 2021

T cell regulation: a special job or everyone's responsibility?

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7 January 2021

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

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7 January 2021

JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome

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7 January 2021

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

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7 January 2021

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

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7 January 2021

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

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7 January 2021

Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis

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7 January 2021

Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education

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7 January 2021

Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes

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7 January 2021

The amount of scurfin protein determines peripheral T cell number and responsiveness

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7 January 2021

Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation

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7 January 2021

An essential role for Scurfin in CD4+CD25+ T regulatory cells

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7 January 2021

Control of regulatory T cell development by the transcription factor Foxp3

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7 January 2021

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

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7 January 2021

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

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7 January 2021

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

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7 January 2021

Identifiers

DOI

10.1038/NI1179

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Dimensions Publication ID

12 August 2017

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