Highly efficient and specific modulation of cardiac calcium homeostasis by adenovector-derived short hairpin RNA targeting phospholamban (Q45863016)

17 December 2017

title

Highly efficient and specific modulation of cardiac calcium homeostasis by adenovector-derived short hairpin RNA targeting phospholamban (English)

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17 December 2017

12

Erdmann VA

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17 December 2017

author name string

Fechner H

1

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17 December 2017

Suckau L

2

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17 December 2017

Kurreck J

3

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17 December 2017

Sipo I

4

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17 December 2017

Wang X

5

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17 December 2017

Pinkert S

6

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17 December 2017

Loschen S

7

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17 December 2017

Rekittke J

8

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17 December 2017

Weger S

9

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17 December 2017

Dekkers D

10

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17 December 2017

Vetter R

11

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17 December 2017

Schultheiss HP

13

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17 December 2017

Paul M

14

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17 December 2017

Lamers J

15

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17 December 2017

Poller W

16

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17 December 2017

publication date

5 October 2006

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17 December 2017

published in

Gene Therapy

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17 December 2017

volume

14

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17 December 2017

issue

3

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17 December 2017

page(s)

211-218

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17 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.gt.3302872

exact match

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cites work

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Expression of slow skeletal troponin I in hearts of phospholamban knockout mice alters the relaxant effect of beta-adrenergic stimulation

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Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation

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Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats.

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Adenovirus-based phospholamban antisense expression as a novel approach to improve cardiac contractile dysfunction: comparison of a constitutive viral versus an endothelin-1-responsive cardiac promoter

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Construction of phospholamban antisense RNA recombinant adeno-associated virus vector and its effects in rat cardiomyocytes.

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Effects of mutant and antisense RNA of phospholamban on SR Ca(2+)-ATPase activity and cardiac myocyte contractility

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Targeting phospholamban by gene transfer in human heart failure

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Gene transfer of a phospholamban-targeted antibody improves calcium handling and cardiac function in heart failure

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The vmax of the Ca2+-ATPase of cardiac sarcoplasmic reticulum (SERCA2a) is not altered by Ca2+/calmodulin-dependent phosphorylation or by interaction with phospholamban

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Modulation of ventricular function through gene transfer in vivo

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Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failure

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Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure

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Systemic delivery of genes to striated muscles using adeno-associated viral vectors.

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Widespread and early myocardial gene expression by adeno-associated virus vector type 6 with a beta-actin hybrid promoter.

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Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8.

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Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human

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The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling

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Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy

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Tamoxifen-regulated adenoviral E1A chimeras for the control of tumor selective oncolytic adenovirus replication in vitro and in vivo

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'Autoreplication' of the vector genome in recombinant adenoviral vectors with different E1 region deletions and transgenes

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Trans-complementation of vector replication versus Coxsackie-adenovirus-receptor overexpression to improve transgene expression in poorly permissive cancer cells

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7 January 2021

A recombinant antibody increases cardiac contractility by mimicking phospholamban phosphorylation

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7 January 2021

Phospholamban ablation by RNA interference increases Ca2+ uptake into rat cardiac myocyte sarcoplasmic reticulum

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7 January 2021

Efficient delivery of siRNA for inhibition of gene expression in postnatal mice

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Transgenic overexpression of the sarcoplasmic reticulum Ca2+ATPase improves reticular Ca2+ handling in normal and diabetic rat hearts.

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7 January 2021

Influence of different culture conditions on sarcoplasmic reticular calcium transport in isolated neonatal rat cardiomyocytes

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7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302872

1 reference

17 December 2017

Dimensions Publication ID

0 references

1 reference

17 December 2017