Kidney-targeting Smad7 gene transfer inhibits renal TGF-β/MAD homologue (SMAD) and nuclear factor κB (NF-κB) signalling pathways, and improves diabetic nephropathy in mice (Q45875016)

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scientific article published on 16 November 2011

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English	Kidney-targeting Smad7 gene transfer inhibits renal TGF-β/MAD homologue (SMAD) and nuclear factor κB (NF-κB) signalling pathways, and improves diabetic nephropathy in mice	scientific article published on 16 November 2011

Statements

scholarly article

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

Kidney-targeting Smad7 gene transfer inhibits renal TGF-β/MAD homologue (SMAD) and nuclear factor κB (NF-κB) signalling pathways, and improves diabetic nephropathy in mice (English)

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

0 references

diabetic nephropathy

1 reference

based on heuristic

inferred from title

author name string

S M Ka

1

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

Y C Yeh

2

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

X R Huang

3

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

T K Chao

4

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

Y J Hung

5

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

C P Yu

6

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

T J Lin

7

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

C C Wu

8

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

H Y Lan

9

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

A Chen

10

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

publication date

16 November 2011

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

55

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Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

2

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Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

509-519

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Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

https://scigraph.springernature.com/pub.10.1007/s00125-011-2364-5

0 references

Diabetic Nephropathy in Type 2 Diabetes Prevention and Patient Management

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Application of an adenoviral vector encoding soluble transforming growth factor-beta type II receptor to the treatment of diabetic nephropathy in mice

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Podocyte loss and progressive glomerular injury in type II diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Extracellular matrix metabolism in diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Glycemic control and complications in type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Central role of TGF-beta in the pathogenesis of diabetic nephropathy and macrovascular complications: a hypothesis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Connective tissue growth factor: potential role in glomerulosclerosis and tubulointerstitial fibrosis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Divergent effects of low versus high dose anti-TGF-beta antibody in puromycin aminonucleoside nephropathy in rats

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Smad7 gene therapy ameliorates an autoimmune crescentic glomerulonephritis in mice.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Diabetic kidney disease in thedb/dbmouse

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

A PAI-1 mutant, PAI-1R, slows progression of diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Peripheral osmotic stimulation inhibits the brain's innate immune response to microdialysis of acidic perfusion fluid adjacent to supraoptic nucleus

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Decoy receptor 3 ameliorates an autoimmune crescentic glomerulonephritis model in mice

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Calcium-binding proteins annexin A2 and S100A6 are sensors of tubular injury and recovery in acute renal failure

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Apoptosis in podocytes induced by TGF-beta and Smad7

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

High glucose evokes an intrinsic proapoptotic signaling pathway in mesangial cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Attenuation of interstitial fibrosis and tubular apoptosis in db/db transgenic mice overexpressing catalase in renal proximal tubular cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Mechanical stretch and prostaglandin E2 modulate critical signaling pathways in mouse podocytes.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Hyperglycemic kidney damage in an animal model of prolonged critical illness.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2364-5

21 January 2018

Nephrin dissociates from actin, and its expression is reduced in early experimental membranous nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22086159

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relationship among nephrin, podocin, CD2AP, and alpha-actinin might not be a true 'interaction' in podocyte

1 reference

https://pubmed.ncbi.nlm.nih.gov/22086159

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenic role of TGF-β in the progression of podocyte diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22086159

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of transforming growth factor-beta isoforms in human glomerular diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22086159

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 2 diabetic patients with nephropathy show structural-functional relationships that are similar to type 1 disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22086159

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetic nephropathy -- a multifaceted target of new therapies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22086159

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of NFkappaB activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22086159

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for existence of polyol pathway in cultured rat mesangial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22086159

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression patterns of connective tissue growth factor and of TGF-beta isoforms during glomerular injury recapitulate glomerulogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22086159

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22086159

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22086159

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-011-2364-5

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

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0 references

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/22086159

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