Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy (Q45877519)

17 December 2017

title

Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy (English)

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17 December 2017

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4

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Francesco Ferraguti

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Annamaria Vezzani

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object named as

Annamaria Vezzani

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Allan-Hermann Pool

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Asla Pitkänen

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object named as

Asla Pitkänen

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author name string

Francesco Noè

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17 December 2017

Jari Nissinen

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Ross Bland

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Massimo Rizzi

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Claudia Balducci

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Gunther Sperk

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Matthew J During

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language of work or name

English

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publication date

13 May 2008

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17 December 2017

published in

Brain

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volume

131

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issue

Pt 6

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page(s)

1506-1515

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Enhanced rate of expression and biosynthesis of neuropeptide Y after kainic acid-induced seizures

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The anti-epileptic actions of neuropeptide Y in the hippocampus are mediated by Y and not Y receptors

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Pattern of neuronal death in the rat hippocampus after status epilepticus. Relationship to calcium binding protein content and ischemic vulnerability

21 January 2018

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Anticonvulsant properties of BIBP3226, a non-peptide selective antagonist at neuropeptide Y Y1 receptors.

21 January 2018

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Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion

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On the sites of presynaptic inhibition by neuropeptide Y in rat hippocampus in vitro.

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Early identification of refractory epilepsy

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Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development

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Galanin and galanin receptors in epilepsy

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Adeno-associated virus-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity in vivo

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A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat.

21 January 2018

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Agonist- and antagonist-induced sequestration/internalization of neuropeptide Y Y1 receptors in HEK293 cells

21 January 2018

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Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy

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Modification of seizure activity by electrical stimulation. II. Motor seizure

21 January 2018

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Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus.

21 January 2018

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The neurobiology of antiepileptic drugs

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Progression of temporal lobe epilepsy in the rat is associated with immunocytochemical changes in inhibitory interneurons in specific regions of the hippocampal formation

21 January 2018

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Seizure susceptibility and epileptogenesis are decreased in transgenic rats overexpressing neuropeptide Y.

21 January 2018

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Overexpression of NPY and Y2 receptors in epileptic brain tissue: an endogenous neuroprotective mechanism in temporal lobe epilepsy?

21 January 2018

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Neuropeptide Y: emerging evidence for a functional role in seizure modulation.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/BRAIN/AWN079

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17 December 2017

PubMed ID

18477594

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17 December 2017