The neurobiology of antiepileptic drugs (Q28267900)

Nature Reviews Neuroscience

Europe PubMed Central

title

The neurobiology of antiepileptic drugs (English)

0 references

1 reference

2

0 references

author name string

Michael A Rogawski

series ordinal

1

0 references

language of work or name

English

0 references

publication date

July 2004

0 references

published in

0 references

volume

5

0 references

issue

7

0 references

page(s)

553-64

0 references

cites work

Enhanced inactivation and acceleration of activation of the sodium channel associated with epilepsy in man

1 reference

Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels

20 April 2017

1 reference

Molecular basis of an inherited epilepsy

20 April 2017

1 reference

Structure and regulation of voltage-gated Ca2+ channels

20 April 2017

1 reference

Inhibition of K(+)-evoked glutamate release from rat neocortical and hippocampal slices by gabapentin

20 April 2017

1 reference

Selective blockade of N-type calcium channels by levetiracetam

20 April 2017

1 reference

Association between genetic variation of CACNA1H and childhood absence epilepsy

20 April 2017

1 reference

Gating effects of mutations in the Cav3.2 T-type calcium channel associated with childhood absence epilepsy

20 April 2017

1 reference

Genetic variation of CACNA1H in idiopathic generalized epilepsy

20 April 2017

1 reference

A splice-site mutation in GABRG2 associated with childhood absence epilepsy and febrile convulsions

20 April 2017

1 reference

Truncation of the GABA(A)-receptor gamma2 subunit in a family with generalized epilepsy with febrile seizures plus

20 April 2017

1 reference

Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy

20 April 2017

1 reference

Felbamate block of recombinant N-methyl-D-aspartate receptors: selectivity for the NR2B subunit

20 April 2017

1 reference

Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures

20 April 2017

1 reference

Coding and noncoding variation of the human calcium-channel beta4-subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia

20 April 2017

1 reference

Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels.

20 April 2017

1 reference

Zonisamide enhances slow sodium inactivation in Myxicola

21 January 2018

1 reference

Felbamate inhibits cloned voltage-dependent Na+ channels from human and rat brain.

21 January 2018

1 reference

Valproate selectively reduces the persistent fraction of Na+ current in neocortical neurons.

21 January 2018

1 reference

Electrophysiological and pharmacological properties of the human brain type IIA Na+ channel expressed in a stable mammalian cell line

21 January 2018

1 reference

Mechanisms of sodium channel inactivation

21 January 2018

1 reference

Na+ channels must deactivate to recover from inactivation.

21 January 2018

1 reference

Increased neuronal firing in computer simulations of sodium channel mutations that cause generalized epilepsy with febrile seizures plus

21 January 2018

1 reference

Limbic epileptogenesis alters the anticonvulsant efficacy of phenytoin in Sprague-Dawley rats.

21 January 2018

1 reference

Differential interactions of lamotrigine and related drugs with transmembrane segment IVS6 of voltage-gated sodium channels

21 January 2018

1 reference

Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.

21 January 2018

1 reference

Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons

21 January 2018

1 reference

Is the persistent sodium current a specific target of anti-absence drugs?

21 January 2018

1 reference

Sodium currents in isolated rat CA1 pyramidal and dentate granule neurones in the post-status epilepticus model of epilepsy

21 January 2018

1 reference

Molecular and functional changes in voltage-dependent Na(+) channels following pilocarpine-induced status epilepticus in rat dentate granule cells

21 January 2018

1 reference

Increased persistent sodium currents in rat entorhinal cortex layer V neurons in a post-status epilepticus model of temporal lobe epilepsy

21 January 2018

1 reference

mRNA coding for voltage-gated sodium channel beta2 subunit in rat central nervous system: cellular distribution and changes following kainate-induced seizures.

21 January 2018

1 reference

The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel

21 January 2018

1 reference

Preferential action of gabapentin and pregabalin at P/Q-type voltage-sensitive calcium channels: inhibition of K+-evoked [3H]-norepinephrine release from rat neocortical slices

21 January 2018

1 reference

Auxiliary subunits: essential components of the voltage-gated calcium channel complex.

21 January 2018

1 reference

Cloning and deletion mutagenesis of the alpha2 delta calcium channel subunit from porcine cerebral cortex. Expression of a soluble form of the protein that retains [3H]gabapentin binding activity.

21 January 2018

1 reference

Structural requirement of the calcium-channel subunit alpha2delta for gabapentin binding

21 January 2018

1 reference

Gabapentin-mediated inhibition of voltage-activated Ca2+ channel currents in cultured sensory neurones is dependent on culture conditions and channel subunit expression.

21 January 2018

1 reference

Gabapentin decreases membrane calcium currents in injured as well as in control mammalian primary afferent neurons

21 January 2018

1 reference

Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain.

21 January 2018

1 reference

Gabapentin and vigabatrin increase GABA in the human neocortical slice

21 January 2018

1 reference

Levetiracetam does not modulate neuronal voltage-gated Na+ and T-type Ca2+ currents

21 January 2018

1 reference

Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices

21 January 2018

1 reference

Molecular physiology of low-voltage-activated t-type calcium channels

21 January 2018

1 reference

Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels

21 January 2018

1 reference

Low-voltage-activated calcium channel subunit expression in a genetic model of absence epilepsy in the rat.

21 January 2018

1 reference

Cortical-area specific block of genetically determined absence seizures by ethosuximide.

21 January 2018

1 reference

Inhibitory control of local excitatory circuits in the guinea-pig hippocampus

21 January 2018

1 reference

Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures

21 January 2018

1 reference

First genetic evidence of GABA(A) receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene

21 January 2018

1 reference

Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones

21 January 2018

1 reference

Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

21 January 2018

1 reference

Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold.

21 January 2018

1 reference

Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).

21 January 2018

1 reference

Activity-dependent enhancement of hyperpolarizing and depolarizing gamma-aminobutyric acid (GABA) synaptic responses following inhibition of GABA uptake by tiagabine.

21 January 2018

1 reference

Refractory status epilepticus: response to ketamine.

21 January 2018

1 reference

Oral ketamine in paediatric non-convulsive status epilepticus

21 January 2018

1 reference

Use-dependent inhibition of the N-methyl-D-aspartate currents by felbamate: a gating modifier with selective binding to the desensitized channels

21 January 2018

1 reference

Kainate receptor pharmacology and physiology

21 January 2018

1 reference

Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist

21 January 2018

1 reference

Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy

21 January 2018

1 reference

Animal models of epileptogenesis

21 January 2018

1 reference

The genetics of human epilepsy

21 January 2018

1 reference

Human epilepsy associated with dysfunction of the brain P/Q-type calcium channel

21 January 2018

1 reference

Low-Threshold Calcium Currents in Central Nervous System Neurons

21 January 2018

1 reference

The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions.

21 January 2018

1 reference

Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine.

31 March 2020

1 reference

Oxcarbazepine: preclinical anticonvulsant profile and putative mechanisms of action.

31 March 2020

1 reference

Electrophysiologic analysis of the actions of valproate on pyramidal neurons in the rat hippocampal slice.

31 March 2020

1 reference

Anticonvulsant pharmacology of voltage-gated Na+ channels in hippocampal neurons of control and chronically epileptic rats

31 March 2020

1 reference

Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurones

31 March 2020

1 reference

Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action.

31 March 2020

1 reference

Selective depression of low-release probability excitatory synapses by sodium channel blockers

31 March 2020

1 reference

Slow inactivation of Na+ current and slow cumulative spike adaptation in mouse and guinea-pig neocortical neurones in slices

31 March 2020

1 reference

Functional effects of two voltage-gated sodium channel mutations that cause generalized epilepsy with febrile seizures plus type 2

31 March 2020

1 reference

Characterization of lamotrigine inhibition of Na+ channels in rat hippocampal neurones

31 March 2020

1 reference

A critical role for transmembrane segment IVS6 of the sodium channel alpha subunit in fast inactivation

31 March 2020

1 reference

Functional analysis of the mouse Scn8a sodium channel.

31 March 2020

1 reference

D1/D5 dopamine receptor activation differentially modulates rapidly inactivating and persistent sodium currents in prefrontal cortex pyramidal neurons.

31 March 2020

1 reference

Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.

31 March 2020

1 reference

Effects of phenytoin on the persistent Na+ current of mammalian CNS neurones.

31 March 2020

1 reference

Calcium channels coupled to glutamate release.

31 March 2020

1 reference

Identification of novel ligands for the gabapentin binding site on the alpha2delta subunit of a calcium channel and their evaluation as anticonvulsant agents

31 March 2020

1 reference

The effect of alpha2-delta and other accessory subunits on expression and properties of the calcium channel alpha1G.

31 March 2020

1 reference

Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones

31 March 2020

1 reference

Gabapentin affects glutamatergic excitatory neurotransmission in the rat dorsal horn

31 March 2020

1 reference

Effects of gabapentin on brain GABA, homocarnosine, and pyrrolidinone in epilepsy patients

31 March 2020

1 reference

Calcium current block by (-)-pentobarbital, phenobarbital, and CHEB but not (+)-pentobarbital in acutely isolated hippocampal CA1 neurons: comparison with effects on GABA-activated Cl- current

31 March 2020

1 reference

Lamotrigine inhibits Ca2+ currents in cortical neurons: functional implications

31 March 2020

1 reference

Inhibition of N-type calcium currents by lamotrigine in rat amygdalar neurones

31 March 2020

1 reference

Low-threshold calcium currents in central nervous system neurons.

31 March 2020

1 reference

T-type calcium channels mediate the transition between tonic and phasic firing in thalamic neurons

31 March 2020

1 reference

Selective increase in T-type calcium conductance of reticular thalamic neurons in a rat model of absence epilepsy

31 March 2020

1 reference

Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons

31 March 2020

1 reference

Block of cloned human T-type calcium channels by succinimide antiepileptic drugs.

31 March 2020

1 reference

On the action of the anti-absence drug ethosuximide in the rat and cat thalamus.

31 March 2020

1 reference

Mechanisms of T-type calcium channel blockade by zonisamide.

31 March 2020

1 reference

Two different mechanisms of disinhibition produced by GABAA receptor mutations linked to epilepsy in humans.

31 March 2020

1 reference

Characterization and ionic basis of GABA-induced depolarizations recorded in vitro from cat primary afferent neurones

31 March 2020

1 reference

Differential effects of extra- and intracellular anions on GABA-activated currents in bullfrog sensory neurons

31 March 2020

1 reference

Mechanism of action of the hypnotic zolpidem in vivo

31 March 2020

1 reference

Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons.

31 March 2020

1 reference

Dynamic GABA(A) receptor subtype-specific modulation of the synchrony and duration of thalamic oscillations.

31 March 2020

1 reference

31 March 2020

GABAA receptor channels

1 reference

Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma.

31 March 2020

1 reference

Reversal of the activity-dependent suppression of GABA-mediated inhibition in hippocampal slices from gamma-vinyl GABA (vigabatrin)-pretreated rats

31 March 2020

1 reference

Paradoxical reduction of synaptic inhibition by vigabatrin

31 March 2020

1 reference

Vigabatrin induces tonic inhibition via GABA transporter reversal without increasing vesicular GABA release.

31 March 2020

1 reference

Dynamic equilibrium of neurotransmitter transporters: not just for reuptake anymore

31 March 2020

1 reference

Effect of inhibitors of GABA transaminase on the synthesis, binding, uptake, and metabolism of GABA

31 March 2020

1 reference

GABA transporters and GABA-transaminase as drug targets

31 March 2020

1 reference

A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor

31 March 2020

1 reference

Effects of the GABA uptake inhibitor tiagabine on inhibitory synaptic potentials in rat hippocampal slice cultures

31 March 2020

1 reference

Laminar difference in GABA uptake and GAT-1 expression in rat CA1.

31 March 2020

1 reference

Molecular physiology of kainate receptors

31 March 2020

1 reference

Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons

31 March 2020

1 reference

The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam

31 March 2020

1 reference

Human epilepsy, episodic ataxia type 2, and migraine

31 March 2020

1 reference

Haplotype and linkage disequilibrium analysis to characterise a region in the calcium channel gene CACNA1A associated with idiopathic generalised epilepsy

31 March 2020

1 reference

Association between the alpha(1a) calcium channel gene CACNA1A and idiopathic generalized epilepsy

31 March 2020

1 reference

Valproate and sodium currents in cultured hippocampal neurons.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Calcium channel alpha(2)delta subunits-structure and Gabapentin binding

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

GluR5 Kainate Receptors, Seizures, and the Amygdala

1 reference