Inhibition of FOXM1 transcription factor suppresses cell proliferation and tumor growth of breast cancer (Q45884239)

17 December 2017

title

Inhibition of FOXM1 transcription factor suppresses cell proliferation and tumor growth of breast cancer (English)

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17 December 2017

author name string

C Yang

1

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17 December 2017

H Chen

2

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17 December 2017

L Yu

3

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17 December 2017

L Shan

4

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17 December 2017

L Xie

5

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17 December 2017

J Hu

6

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17 December 2017

T Chen

7

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17 December 2017

Y Tan

8

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17 December 2017

publication date

11 January 2013

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17 December 2017

published in

Cancer Gene Therapy

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17 December 2017

volume

20

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17 December 2017

issue

2

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17 December 2017

page(s)

117-124

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17 December 2017

https://scigraph.springernature.com/pub.10.1038/cgt.2012.94

exact match

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cites work

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FoxM1 is required for execution of the mitotic programme and chromosome stability

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Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase

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Loss of the forkhead transcription factor FoxM1 causes centrosome amplification and mitotic catastrophe

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Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes

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FoxM1c counteracts oxidative stress-induced senescence and stimulates Bmi-1 expression.

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Foxm1 transcription factor is required for maintenance of pluripotency of P19 embryonal carcinoma cells

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The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer

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FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells

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Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice

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Down-regulation of Forkhead Box M1 transcription factor leads to the inhibition of invasion and angiogenesis of pancreatic cancer cells

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Identification of early molecular markers for breast cancer

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The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells

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FOXM1 is a transcriptional target of ERalpha and has a critical role in breast cancer endocrine sensitivity and resistance

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7 January 2021

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Identifiers

DOI

10.1038/CGT.2012.94

1 reference

17 December 2017

Dimensions Publication ID

0 references

1 reference

17 December 2017