Double E1B 19 kDa- and E1B 55 kDa-deleted oncolytic adenovirus in combination with radiotherapy elicits an enhanced anti-tumor effect (Q45885895)

17 December 2017

title

Double E1B 19 kDa- and E1B 55 kDa-deleted oncolytic adenovirus in combination with radiotherapy elicits an enhanced anti-tumor effect (English)

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17 December 2017

adaptive radiation therapy

main subject

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9

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17 December 2017

author name string

J Kim

1

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17 December 2017

P-H Kim

2

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17 December 2017

J Y Yoo

3

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17 December 2017

A-R Yoon

4

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H J Choi

5

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17 December 2017

J Seong

6

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I-W Kim

7

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J-H Kim

8

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publication date

4 June 2009

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17 December 2017

published in

Gene Therapy

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17 December 2017

volume

16

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issue

9

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17 December 2017

page(s)

1111-1121

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17 December 2017

Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity

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Oncolytic adenovirus CG7870 in combination with radiation demonstrates synergistic enhancements of antitumor efficacy without loss of specificity

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AdDelta24 and the p53-expressing variant AdDelta24-p53 achieve potent anti-tumor activity in glioma when combined with radiotherapy.

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Potentiation of radiation therapy by the oncolytic adenovirus dl1520 (ONYX-015) in human malignant glioma xenografts

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A novel three-pronged approach to kill cancer cells selectively: concomitant viral, double suicide gene, and radiotherapy

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Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins

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Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death.

21 January 2018

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Markedly enhanced cytolysis by E1B-19kD-deleted oncolytic adenovirus in combination with cisplatin

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Evaluation of E1B gene-attenuated replicating adenoviruses for cancer gene therapy.

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Cardiolipin-specific peroxidase reactions of cytochrome C in mitochondria during irradiation-induced apoptosis.

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a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

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Radiation and ceramide-induced apoptosis

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The RB and p53 pathways in cancer

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ADP-overexpressing adenovirus elicits enhanced cytopathic effect by induction of apoptosis

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Use of replicating oncolytic adenoviruses in combination therapy for cancer

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E1A- and E1B-Double mutant replicating adenovirus elicits enhanced oncolytic and antitumor effects

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Ionizing radiation increases adenovirus uptake and improves transgene expression in intrahepatic colon cancer xenografts

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Ionizing radiation-induced adenovirus infection is mediated by Dynamin 2

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The future of gene therapy in the treatment of urologic malignancies

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Radiotherapy-related fatigue

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Replicative oncolytic adenoviruses in multimodal cancer regimens

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ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells

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7 January 2021

CpG oligodeoxynucleotides are potent enhancers of radio- and chemoresponses of murine tumors

1 reference

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7 January 2021

ONYX-015, an E1B gene-defective adenovirus, induces cell death in human anaplastic thyroid carcinoma cell lines

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https://api.crossref.org/works/10.1038%2FGT.2009.72

7 January 2021

Relaxin expression from tumor-targeting adenoviruses and its intratumoral spread, apoptosis induction, and efficacy

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https://api.crossref.org/works/10.1038%2FGT.2009.72

7 January 2021

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https://api.crossref.org/works/10.1038%2FGT.2009.72

7 January 2021

Identifiers

DOI

10.1038/GT.2009.72

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17 December 2017

Dimensions Publication ID

1052789775

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17 December 2017