Protection against chronic hypoperfusion-induced retinal neurodegeneration by PARP inhibition via activation of PI-3-kinase Akt pathway and suppression of JNK and p38 MAP kinases. (Q45969399)

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English	Protection against chronic hypoperfusion-induced retinal neurodegeneration by PARP inhibition via activation of PI-3-kinase Akt pathway and suppression of JNK and p38 MAP kinases.	scientific article

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31 January 2020

Protection against chronic hypoperfusion-induced retinal neurodegeneration by PARP inhibition via activation of PI-3-kinase Akt pathway and suppression of JNK and p38 MAP kinases (English)

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31 January 2020

neurodegeneration

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31 January 2020

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31 January 2020

Krisztina Szabadfi

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31 January 2020

Robert Gábriel

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Robert Gabriel

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31 January 2020

Krisztina Kovacs

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31 January 2020

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Aliz Szabo

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31 January 2020

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31 January 2020

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Boglarka Racz

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31 January 2020

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Balazs Sumegi

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31 January 2020

Eniko Hocsak

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31 January 2020

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9 April 2009

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31 January 2020

Neurotoxicity Research

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31 January 2020

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31 January 2020

1

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31 January 2020

68-76

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31 January 2020

https://scigraph.springernature.com/pub.10.1007/s12640-009-9049-6

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Ophthalmologic manifestations of carotid occlusive disease

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21 January 2018

Signaling of Cell Death and Cell Survival Following Focal Cerebral Ischemia: Life and Death Struggle in the Penumbra

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21 January 2018

Alpha-2 adrenoceptor agonist protects retinal function after acute retinal ischemic injury in the rat.

1 reference

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21 January 2018

Mitogen-activated protein kinases and retinal ischemia

1 reference

https://api.crossref.org/works/10.1007%2FS12640-009-9049-6

21 January 2018

Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Complex neurodegeneration in retina following moderate ischemia induced by bilateral common carotid artery occlusion in Wistar rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Broad spectrum caspase inhibitor rescues retinal ganglion cells after ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

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Nicotinamide blocks N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in rats through poly (ADP-ribose) polymerase activity and Jun N-terminal kinase/activator protein-1 pathway inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Intrinsic activation of PI3K/Akt signaling pathway and its neuroprotective effect against retinal injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Increased expression and activation of poly(ADP-ribose) polymerase (PARP) contribute to retinal ganglion cell death following rat optic nerve transection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Inhibition of ADP-evoked platelet aggregation by selected poly(ADP-ribose) polymerase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Neurodegeneration and cellular stress in the retina and optic nerve in rat cerebral ischemia and hypoperfusion models

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Neurovascular mechanisms of Alzheimer's neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Chronic bilateral common carotid artery occlusion: a model for ocular ischemic syndrome in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Oxidative-induced apoptosis to an immortalized ganglion cell line is caspase independent but involves the activation of poly(ADP-ribose)polymerase and apoptosis-inducing factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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PI3K/akt, JAK/STAT and MEK/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Ischemic preconditioning attenuates apoptotic cell death in the rat retina

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Effect of erythropoietin axotomy-induced apoptosis in rat retinal ganglion cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Poly(ADP-ribose) polymerase contributes to the development of myocardial infarction in diabetic rats and regulates the nuclear translocation of apoptosis-inducing factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Preventing polyglutamine-induced activation of c-Jun delays neuronal dysfunction in a mouse model of SCA7 retinopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of pro-survival and death-associated pathways under retinal ischemia/reperfusion: effects of NMDA receptor blockade.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Riluzole improves functional recovery after ischemia in the rat retina

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that Alzheimer's disease is a microvascular disorder: the role of constitutive nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Study of the oxidative stress in a rat model of chronic brain hypoperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Death and neuroprotection of retinal ganglion cells after different types of injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

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Decrease of the inflammatory response and induction of the Akt/protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

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Retinal ischemia: mechanisms of damage and potential therapeutic strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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MAP kinase pathways in UV-induced apoptosis of retinal pigment epithelium ARPE19 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

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Rat strain and vendor differences in collateral anastomoses

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

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Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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The effect of 3-aminobenzamide, an inhibitor of poly-ADP-ribose polymerase, on ischemia/reperfusion damage in rat retina

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Presence of mitogen-activated protein kinase in retinal Müller cells and its neuroprotective effect ischemia-reperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Modulation of transcription by PARP-1: consequences in carcinogenesis and inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Role of PARP-1 and PARP-2 in the expression of apoptosis-regulating genes in HeLa cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

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Experimental carotid occlusion: funduscopic and fluorescein angiographic findings

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

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Diazoxide is protective in the rat retina against ischemic injury induced by bilateral carotid occlusion and glutamate-induced degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Poly(ADP-ribose) polymerase as a key player in excitotoxicity and post-ischemic brain damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcineurin mediates AKT dephosphorylation in the ischemic rat retina

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of PARP activity attenuates poly(ADP-ribosyl)ation but offers only partial neuroprotection against NMDA-induced cell death in the rat retina

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of pituitary adenylate cyclase activating polypeptide (PACAP) on the PKA-Bad-14-3-3 signaling pathway in glutamate-induced retinal injury in neonatal rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ramipril protects from free radical induced white matter damage in chronic hypoperfusion in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Baicalein protects rat brain mitochondria against chronic cerebral hypoperfusion-induced oxidative damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase activating polypeptide is protective in bilateral carotid occlusion-induced retinal lesion in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myosin translocation in retinal pericytes during free-radical induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Poly(ADP-ribose) accumulation and enhancement of postischemic brain damage in 110-kDa poly(ADP-ribose) glycohydrolase null mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-treatment at 12 or 18 hours with 3-aminobenzamide ameliorates retinal ischemia-reperfusion damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose)polymerase-1 inhibition in oxidative stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of poly(ADP-ribose) polymerase-1 in CNS disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of KCL-440, a new poly(ADP-ribose) polymerase inhibitor, in the rat middle cerebral artery occlusion model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of mitogen-activated protein kinases to NMDA-induced neurotoxicity in the rat retina.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoperfusion of the cerebral white matter in multiple sclerosis: possible mechanisms and pathophysiological significance.

1 reference

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12 December 2020

based on heuristic

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The therapeutic potential of poly(ADP-ribose) polymerase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excessive Activation of Poly(ADP-Ribose) Polymerase Contributes to Inherited Photoreceptor Degeneration in the Retinal Degeneration 1 Mouse

1 reference

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12 December 2020

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Differential, age-dependent MEK-ERK and PI3K-Akt activation by insulin acting as a survival factor during embryonic retinal development.

1 reference

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Chronic cerebral hypoperfusion: loss of pupillary reflex, visual impairment and retinal neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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