Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis. (Q45971063)

18 December 2017

title

Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis. (English)

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18 December 2017

author

Jérôme Avouac

5

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18 December 2017

Ladislav Šenolt

8

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18 December 2017

Georg Schett

9

object named as

Georg Schett

1 reference

18 December 2017

Michal Tomcik

1

1 reference

18 December 2017

Pawel Zerr

2

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18 December 2017

Jana Pitkowski

3

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18 December 2017

Katrin Palumbo-Zerr

4

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18 December 2017

Oliver Distler

6

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18 December 2017

Radim Becvar

7

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18 December 2017

Jörg H Distler

10

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18 December 2017

language of work or name

English

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publication date

9 May 2013

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18 December 2017

Annals of the Rheumatic Diseases

published in

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18 December 2017

volume

73

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18 December 2017

issue

6

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18 December 2017

page(s)

1215-1222

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18 December 2017

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

1 reference

Systemic sclerosis: a prototypic multisystem fibrotic disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Systemic and cell type-specific gene expression patterns in scleroderma skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Systemic sclerosis: hypothesis-driven treatment strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Molecular chaperones in cellular protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Roles of heat-shock proteins in innate and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Critical regulation of TGFbeta signaling by Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Src kinases in systemic sclerosis: central roles in fibroblast activation and in skin fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Tyrosine kinase signaling in fibrotic disorders: Translation of basic research to human disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Hsp90 inhibitors as anti-cancer agents, from basic discoveries to clinical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Heat shock proteins in cancer: targeting the 'chaperones'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Platelet-derived serotonin links vascular disease and tissue fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

The transcription factor JunD mediates transforming growth factor {beta}-induced fibroblast activation and fibrosis in systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Animal models of systemic sclerosis: prospects and limitations

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Novel therapeutic strategies in multiple myeloma: role of the heat shock protein inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

HSP90 Inhibitors: Current Development and Potential in Cancer Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

Update on Hsp90 inhibitors in clinical trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-203095

10.1136/ANNRHEUMDIS-2012-203095

21 January 2018

Identifiers

DOI

1 reference

18 December 2017

PubMed ID

23661493

1 reference

18 December 2017