Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics (Q34140962)

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English	Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics	scientific article

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scholarly article

1 reference

Europe PubMed Central

31 July 2017

Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics (English)

1 reference

Europe PubMed Central

31 July 2017

1 reference

ChEBI release 2020-05-28

10

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Europe PubMed Central

31 July 2017

12

object named as

Hans Lehrach

1 reference

Europe PubMed Central

31 July 2017

object named as

Martin Kerick

8

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object named as

Gerard Drewes

14

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Cayetano Gonzalez

object named as

Cayetano Gonzalez

13

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Holger Fröhlich

object named as

Holger Fröhlich

4

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author name string

Armin Haupt

1

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Europe PubMed Central

31 July 2017

Gerard Joberty

2

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Europe PubMed Central

31 July 2017

Marcus Bantscheff

3

1 reference

Europe PubMed Central

31 July 2017

Henning Stehr

5

1 reference

Europe PubMed Central

31 July 2017

Michal R Schweiger

6

1 reference

Europe PubMed Central

31 July 2017

Axel Fischer

7

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Europe PubMed Central

31 July 2017

Stefan T Boerno

9

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Europe PubMed Central

31 July 2017

Michael Lappe

11

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31 July 2017

Bodo Mh Lange

15

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31 July 2017

language of work or name

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publication date

25 January 2012

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Europe PubMed Central

31 July 2017

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Europe PubMed Central

31 July 2017

12

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Europe PubMed Central

31 July 2017

38

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Europe PubMed Central

31 July 2017

https://scigraph.springernature.com/pub.10.1186/1471-2407-12-38

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Bone morphogenetic protein and bone metastasis, implication and therapeutic potential

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28 July 2018

Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.

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28 July 2018

Targeting the dynamic HSP90 complex in cancer

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28 July 2018

Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy

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28 July 2018

A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein

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Signal integration by JNK and p38 MAPK pathways in cancer development

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Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

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Novel Hsp90 partners discovered using complementary proteomic approaches

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A phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer

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28 July 2018

Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone

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28 July 2018

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

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Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway

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Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

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28 July 2018

Proteome-wide changes induced by the Hsp90 inhibitor, geldanamycin in anaplastic large cell lymphoma cells

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28 July 2018

Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin.

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28 July 2018

High HSP90 expression is associated with decreased survival in breast cancer

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28 July 2018

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

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28 July 2018

A proteomic snapshot of the human heat shock protein 90 interactome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342885

28 July 2018

HSP90 and the chaperoning of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342885

28 July 2018

First evidence supporting a potential role for the BMP/SMAD pathway in the progression of oestrogen receptor-positive breast cancer.

1 reference

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28 July 2018

Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342885

28 July 2018

Loss of expression of bone morphogenetic protein receptor type II in human prostate cancer cells

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28 July 2018

The KEGG resource for deciphering the genome

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28 July 2018

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342885

28 July 2018

Hsp90: chaperoning signal transduction

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28 July 2018

Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone.

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28 July 2018

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342885

28 July 2018

Expression and roles of heat shock proteins in human breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342885

28 July 2018

A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p).

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-12-38

21 January 2018

Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches.

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21 January 2018

Targeted data acquisition for improved reproducibility and robustness of proteomic mass spectrometry assays

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21 January 2018

Inhibitors of the HSP90 molecular chaperone: current status

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21 January 2018

The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer.

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21 January 2018

Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators.

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28 October 2018

Overexpression of a dominant negative type II bone morphogenetic protein receptor inhibits the growth of human breast cancer cells.

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28 October 2018

Expression of bone morphogenetic protein receptors type-IA, -IB and -II correlates with tumor grade in human prostate cancer tissues

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Hsp90 Recognizes a Common Surface on Client Kinases

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https://api.crossref.org/works/10.1186%2F1471-2407-12-38

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Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines

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12 December 2020

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Novel subunits of the mammalian Hsp90 signal transduction chaperone

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https://pubmed.ncbi.nlm.nih.gov/22277058

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based on heuristic

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10.1186/1471-2407-12-38

1 reference

Europe PubMed Central

31 July 2017

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1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

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