Hyperglycaemia and hyperinsulinaemia: is insulin-degrading enzyme the missing link? (Q45979118)

18 December 2017

title

Hyperglycaemia and hyperinsulinaemia: is insulin-degrading enzyme the missing link? (English)

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18 December 2017

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J Fawcett

1

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18 December 2017

W C Duckworth

series ordinal

2

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18 December 2017

language of work or name

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6 June 2009

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18 December 2017

published in

Diabetologia

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18 December 2017

volume

52

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18 December 2017

issue

8

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18 December 2017

page(s)

1457-1460

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18 December 2017

Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

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IRS proteins and the common path to diabetes

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Metalloendoprotease inhibitors which block the differentiation of L6 myoblasts inhibit insulin degradation by the endogenous insulin-degrading enzyme

21 January 2018

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Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes

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12 December 2020

Degradation of intraendosomal insulin by insulin-degrading enzyme without acidification

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Insulin inhibits peroxisomal fatty acid oxidation in isolated rat hepatocytes

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Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study

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The functional significance of Shc in insulin signaling as a substrate of the insulin receptor

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Effects of metalloendoprotease inhibitors on insulin binding, internalization and processing in adipocytes

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Insulin inhibition of the proteasome is dependent on degradation of insulin by insulin-degrading enzyme

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12 December 2020

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

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12 December 2020

Insulin acts intracellularly on proteasomes through insulin-degrading enzyme

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12 December 2020

Glucose inhibits the insulin-induced activation of the insulin-degrading enzyme in HepG2 cells.

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12 December 2020

Regulation of multicatalytic enzyme activity by insulin and the insulin-degrading enzyme

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Role of yeast insulin-degrading enzyme homologs in propheromone processing and bud site selection

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12 December 2020

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

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12 December 2020

The effect of insulin concentration on retroendocytosis in isolated rat adipocytes

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12 December 2020

Characterization of the inhibition of protein degradation by insulin in L6 cells

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12 December 2020

Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein

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12 December 2020

ATP inhibits insulin-degrading enzyme activity

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12 December 2020

Androgen and glucocorticoid receptors interact with insulin degrading enzyme.

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12 December 2020

Reduced action of insulin glargine on protein and lipid metabolism: possible relationship to cellular hormone metabolism

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12 December 2020

Identification and isolation of a cytosolic proteolytic complex containing insulin degrading enzyme and the multicatalytic proteinase

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Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III

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Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE.

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Genetic variation in a haplotype block spanningIDE influences Alzheimer disease

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Processing and presentation of insulin. III. Insulin degrading enzyme: a neutral metalloendoproteinase that is non-homologous to classical endoproteinases mediates the processing of insulin epitopes for helper T cells

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In VitroInhibition of Insulin-Degrading Enzyme by Long-Chain Fatty Acids and Their Coenzyme A Thioesters

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Insulin degradation: progress and potential

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12 December 2020

Regulation of protein degradation by insulin-degrading enzyme: analysis by small interfering RNA-mediated gene silencing

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10.1007/S00125-009-1414-8

Identifiers

DOI

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18 December 2017

Dimensions Publication ID

1015549892

0 references

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18 December 2017