Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria (Q24300365)

GOA release 2020-03-11

1 reference

1 reference

7

Dennis J Selkoe

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Leonard P. Guarente

6

object named as

Leonard Guarente

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Marcia C. Haigis

5

object named as

Marcia C Haigis

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author name string

Malcolm A Leissring

1

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Wesley Farris

2

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Xining Wu

3

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Danos C Christodoulou

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

4

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language of work or name

English

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publication date

1 November 2004

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published in

Biochemical Journal

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volume

383

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page(s)

439-46

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issue

Pt. 3

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cites work

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Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

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Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

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Role of yeast insulin-degrading enzyme homologs in propheromone processing and bud site selection

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Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

19 March 2017

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Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

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Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

7 April 2017

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Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

7 April 2017

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27 September 2017

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Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study

27 September 2017

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27 September 2017

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Mitochondria as the conductor of metabolic signals for insulin exocytosis in pancreatic beta-cells.

27 September 2017

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Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques.

27 September 2017

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27 September 2017

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Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats

27 September 2017

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27 September 2017

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27 September 2017

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N-arginine dibasic convertase (NRD convertase): a newcomer to the family of processing endopeptidases. An overview

27 September 2017

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Identification of zinc ligands of the insulin-degrading enzyme.

27 September 2017

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Arginine in the leader peptide is required for both import and proteolytic cleavage of a mitochondrial precursor

27 September 2017

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Production of spontaneous diabetic rats by repetition of selective breeding

27 September 2017

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Insulin and cognitive function in an elderly population. The Rotterdam Study.

27 September 2017

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Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme.

30 May 2018

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Association of diabetes mellitus and dementia: the Rotterdam Study.

30 May 2018

1 reference

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Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

30 May 2018

1 reference

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Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133736

Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE).

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133736

Increased vulnerability of brain mitochondria in diabetic (Goto-Kakizaki) rats with aging and amyloid-beta exposure.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133736

Confirmation of association between D10S583 and Alzheimer's disease in a case--control sample.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133736

Diabetes mellitus and the risk of dementia: The Rotterdam Study.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133736

The risk of dementia among persons with diabetes mellitus: a population-based cohort study.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133736

Targeting of endopeptidase 24.16 to different subcellular compartments by alternative promoter usage.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133736

Overexpression of insulin degrading enzyme: cellular localization and effects on insulin signaling

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133736

Hyperinsulinaemia and Alzheimer's disease.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133736

A metalloprotease involved in the processing of mitochondrial precursor proteins.

29 November 2018

1 reference

12 December 2020

Regulation of multicatalytic enzyme activity by insulin and the insulin-degrading enzyme

1 reference

12 December 2020

Functional human insulin-degrading enzyme can be expressed in bacteria

1 reference

12 December 2020

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q

1 reference

12 December 2020

Isolation and identification of a novel mitochondrial metalloprotease (PreP) that degrades targeting presequences in plants

1 reference

12 December 2020

Identifiers

DOI

10.1042/BJ20041081

1 reference

Consolidated OpenCitations Corpus – April 2017

release_nc5jdd37c5ap5gtffos5rusn34

1196019

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/nc5jdd37c5ap5gtffos5rusn34

24 November 2022

mapped directly with Wikidata item

1196019

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

0 references

1 reference