PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity. (Q45998535)

18 December 2017

title

PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity. (English)

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18 December 2017

author name string

Angus J M Cameron

1

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18 December 2017

Cristina Escribano

2

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18 December 2017

Adrian T Saurin

3

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18 December 2017

Brenda Kostelecky

4

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18 December 2017

Peter J Parker

5

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18 December 2017

publication date

24 May 2009

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18 December 2017

Nature Structural & Molecular Biology

published in

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18 December 2017

volume

16

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18 December 2017

issue

6

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18 December 2017

page(s)

624-630

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18 December 2017

Multiple pathways control protein kinase C phosphorylation

cites work

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A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

21 January 2018

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Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation

21 January 2018

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The extended protein kinase C superfamily

21 January 2018

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Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAP

21 January 2018

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The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation

21 January 2018

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Regulation of novel protein kinase C epsilon by phosphorylation.

21 January 2018

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Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

21 January 2018

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

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Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Calpha.

21 January 2018

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Magic bullets for protein kinases

21 January 2018

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The identification and characterization of novel PKCepsilon phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily

21 January 2018

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Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits

21 January 2018

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Emerging roles of pseudokinases

21 January 2018

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PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival

21 January 2018

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The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A.

21 January 2018

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Crystal structure of an inactive Akt2 kinase domain

21 January 2018

1 reference

Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP-PNP

21 January 2018

1 reference

The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein.

21 January 2018

1 reference

Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor

21 January 2018

1 reference

Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif

21 January 2018

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Catalytic domain crystal structure of protein kinase C-theta (PKCtheta).

21 January 2018

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Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

21 January 2018

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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

21 January 2018

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Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

21 January 2018

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Dephosphorylation of PKCdelta by protein phosphatase 2Ac and its inhibition by nucleotides

21 January 2018

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Bypassing a Kinase Activity with an ATP-Competitive Drug

21 January 2018

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Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon

21 January 2018

1 reference

Multisite dephosphorylation and desensitization of conventional protein kinase C isotypes

21 January 2018

1 reference

The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis

21 January 2018

1 reference

The role of protein kinase C in cell surface signal transduction and tumour promotion

21 January 2018

2 references

21 January 2018

12 December 2020

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

Phosphorylation of protein kinase C-alpha on serine 657 controls the accumulation of active enzyme and contributes to its phosphatase-resistant state

31 March 2020

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Loss of protein kinase C function induces an apoptotic response

31 March 2020

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Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C

31 March 2020

1 reference

A point mutation at the putative ATP-binding site of protein kinase C alpha abolishes the kinase activity and renders it down-regulation-insensitive. A molecular link between autophosphorylation and down-regulation

31 March 2020

1 reference

PubMed

12 December 2020

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.

1 reference

PubMed

12 December 2020

Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions

1 reference

PubMed

12 December 2020

Identifiers

DOI

10.1038/NSMB.1606

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18 December 2017

Dimensions Publication ID

1041008301

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18 December 2017