Crystal structure of an inactive Akt2 kinase domain (Q27640282)

2

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Kurt A Morgenstern

3

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Yan Gu

4

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Paul Rose

5

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Huilin Zhao

6

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Xiaotian Zhu

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

7

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publication date

January 2003

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published in

Structure

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volume

11

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issue

1

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page(s)

21-30

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cites work

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Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

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Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

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Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

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Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.

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Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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Role of AKT1 in 17beta-estradiol- and insulin-like growth factor I (IGF-I)-dependent proliferation and prevention of apoptosis in MCF-7 breast carcinoma cells

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A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

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The PI3K-PDK1 connection: more than just a road to PKB

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Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

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Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

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Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

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Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine

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Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase

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Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: its role in inhibition of tumor promotion

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Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

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Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

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Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

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The protein kinase resource

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Protein kinase C signaling and oxidative stress

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Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

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The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

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Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

3834254

3834254

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference