Pharmacokinetics of temozolomide administered in combination with O6-benzylguanine in children and adolescents with refractory solid tumors. (Q46017033)

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27 January 2020

title

Pharmacokinetics of temozolomide administered in combination with O6-benzylguanine in children and adolescents with refractory solid tumors (English)

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27 January 2020

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6

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27 January 2020

author name string

Holly J Meany

1

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27 January 2020

Katherine E Warren

2

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27 January 2020

Elizabeth Fox

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Diane E Cole

4

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27 January 2020

Alberta A Aikin

5

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publication date

9 May 2009

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Cancer Chemotherapy and Pharmacology

27 January 2020

published in

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volume

65

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issue

1

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page(s)

137-142

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https://scigraph.springernature.com/pub.10.1007/s00280-009-1015-8

27 January 2020

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cites work

Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells

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Phase I study of temozolomide in paediatric patients with advanced cancer. United Kingdom Children's Cancer Study Group

21 January 2018

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O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00280-009-1015-8

3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity

21 January 2018

1 reference

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Inhibition of DNA repair as a means of increasing the antitumor activity of DNA reactive agents

21 January 2018

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12 December 2020

High-performance liquid chromatographic analysis and stability of anti-tumor agent temozolomide in human plasma

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12 December 2020

Temozolomide: a novel oral alkylating agent

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12 December 2020

Population pharmacokinetics of temozolomide and metabolites in infants and children with primary central nervous system tumors

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12 December 2020

Pharmacokinetics of temozolomide given three times a day in pediatric and adult patients

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12 December 2020

Phase I study of O6-benzylguanine and temozolomide administered daily for 5 days to pediatric patients with solid tumors.

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12 December 2020

Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents

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12 December 2020

Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study.

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12 December 2020

Antitumour imidazotetrazines--XVI. Macromolecular alkylation by 3-substituted imidazotetrazinones

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12 December 2020

Antitumor imidazotetrazines--XV. Role of guanine O6 alkylation in the mechanism of cytotoxicity of imidazotetrazinones

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12 December 2020

Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine

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12 December 2020

Determination of temozolomide in human plasma and urine by high-performance liquid chromatography after solid-phase extraction.

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12 December 2020

Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials

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12 December 2020

Involvement of the mismatch repair system in temozolomide-induced apoptosis

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12 December 2020

10.1007/S00280-009-1015-8

Identifiers

DOI

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