Podocyte loss involves MDM2-driven mitotic catastrophe. (Q46048434)

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2 March 2020

title

Podocyte loss involves MDM2-driven mitotic catastrophe (English)

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9

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Paola Romagnani

11

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Elena Lazzeri

8

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Hans-Joachim Anders

12

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author name string

Shrikant R Mulay

1

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2 March 2020

Dana Thomasova

2

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2 March 2020

Mi Ryu

3

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Onkar P Kulkarni

4

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Adriana Migliorini

5

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Hauke Bruns

6

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Regina Gröbmayr

7

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Helen Liapis

10

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publication date

1 July 2013

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volume

230

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page(s)

322-335

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issue

3

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Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene.

2 March 2020

cites work

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Plasma leakage through glomerular basement membrane ruptures triggers the proliferation of parietal epithelial cells and crescent formation in non-inflammatory glomerular injury

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Tumour necrosis factor-α drives Alport glomerulosclerosis in mice by promoting podocyte apoptosis.

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Mitotic cell cycle proteins increase in podocytes despite lack of proliferation.

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DNA damage is a novel response to sublytic complement C5b-9-induced injury in podocytes

21 January 2018

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Notch activation differentially regulates renal progenitors proliferation and differentiation toward the podocyte lineage in glomerular disorders

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Cell death by mitotic catastrophe: a molecular definition

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CDK inhibitor p21 is prosurvival in adriamycin-induced podocyte injury, in vitro and in vivo

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Death through a tragedy: mitotic catastrophe

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CC chemokine ligand 5/RANTES chemokine antagonists aggravate glomerulonephritis despite reduction of glomerular leukocyte infiltration

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Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors.

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Critical contribution of the MDM2 acidic domain to p53 ubiquitination

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Mdm2 promotes the rapid degradation of p53

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

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21 January 2018

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Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

21 January 2018

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21 January 2018

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MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice.

21 January 2018

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p53-independent roles of MDM2 in NF-κB signaling: implications for cancer therapy, wound healing, and autoimmune diseases

21 January 2018

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Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3'PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice.

21 January 2018

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CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome

21 January 2018

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Adriamycin nephropathy: a model of focal segmental glomerulosclerosis.

21 January 2018

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Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4.

21 January 2018

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Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis

21 January 2018

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Chemokines and chemokine receptors as therapeutic targets in lupus nephritis

21 January 2018

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Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype

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Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-kappaB signaling.

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Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis.

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The podocyte's response to stress: the enigma of foot process effacement

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Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling

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The Notch pathway in podocytes plays a role in the development of glomerular disease

21 January 2018

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Podocyte mitosis - a catastrophe.

21 January 2018

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Rapamycin attenuates the severity of murine adriamycin nephropathy

21 January 2018

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Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

21 January 2018

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mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/PATH.4193

1 reference

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2 March 2020

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