Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy (Q24651380)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18834305%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

review article

1 reference

title

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18834305%20AND%20SRC:MED&resulttype=core&format=json

protein-protein interaction

15 January 2020

main subject

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18834305%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

author name string

Sanjeev Shangary

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18834305%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

language of work or name

English

0 references

publication date

1 January 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18834305%20AND%20SRC:MED&resulttype=core&format=json

Annual Review of Pharmacology and Toxicology

15 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18834305%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

volume

49

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18834305%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

page(s)

223-241

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18834305%20AND%20SRC:MED&resulttype=core&format=json

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

15 January 2020

issue

1

0 references

cites work

1 reference

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MDMX: a novel p53-binding protein with some functional properties of MDM2

7 April 2017

1 reference

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

7 April 2017

1 reference

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Molecular basis for the inhibition of p53 by Mdmx

7 April 2017

1 reference

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

7 April 2017

1 reference

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7 April 2017

Surfing the p53 network

1 reference

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Hdmx modulates the outcome of p53 activation in human tumor cells

7 April 2017

1 reference

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Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

7 April 2017

1 reference

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MDM2--master regulator of the p53 tumor suppressor protein

7 April 2017

1 reference

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MDM2 interacts with MDMX through their RING finger domains

7 April 2017

1 reference

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Functions of the MDM2 oncoprotein

7 April 2017

1 reference

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14-3-3sigma is a p53-regulated inhibitor of G2/M progression

7 April 2017

1 reference

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Development and validation of a genetic algorithm for flexible docking

7 April 2017

1 reference

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

7 April 2017

1 reference

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Amplification of a gene encoding a p53-associated protein in human sarcomas

7 April 2017

1 reference

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

7 April 2017

1 reference

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The p53-mdm-2 autoregulatory feedback loop

7 April 2017

1 reference

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Mapping of the p53 and mdm-2 interaction domains

7 April 2017

1 reference

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Live or let die: the cell's response to p53

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

7 April 2017

1 reference

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Restoration of p53 function leads to tumour regression in vivo

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Improved protein-ligand docking using GOLD

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

p53 is required for radiation-induced apoptosis in mouse thymocytes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

T antigen is bound to a host protein in SY40-transformed cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Inhibition of the p53 E3 ligase HDM-2 induces apoptosis and DNA damage--independent p53 phosphorylation in mantle cell lymphoma

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Targeting the MDM2-p53 interaction for cancer therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Cyclin-dependent kinase inhibitors sensitize tumor cells to nutlin-induced apoptosis: a potent drug combination.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Small molecule inhibitors of the MDM2-p53 interaction discovered by ensemble-based receptor models.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas.

28 September 2017

1 reference

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Modeling the therapeutic efficacy of p53 restoration in tumors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

MDM2 inhibitors for cancer therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Nongenotoxic p53 activation protects cells against S-phase-specific chemotherapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Strategies for therapeutic targeting of the p53 pathway in cancer.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo

28 September 2017

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Nongenotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma

28 September 2017

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MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

28 September 2017

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p53 alpha-Helix mimetics antagonize p53/MDM2 interaction and activate p53.

28 September 2017

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Chalcones: an update on cytotoxic and chemoprotective properties

28 September 2017

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MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy

28 September 2017

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MDM2 is a central node in the p53 pathway: 12 years and counting

28 September 2017

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Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

28 September 2017

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1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2-p53 interaction: discovery and SAR.

28 September 2017

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Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

28 September 2017

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A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

28 September 2017

1 reference

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Mutational spectrum of p53 mutations in primary breast and ovarian tumors.

28 September 2017

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Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis

28 September 2017

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A nonpeptidic sulfonamide inhibits the p53-mdm2 interaction and activates p53-dependent transcription in mdm2-overexpressing cells

28 September 2017

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Small-molecule antagonists of p53-MDM2 binding: research tools and potential therapeutics.

28 September 2017

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Control of apoptosis by p53.

28 September 2017

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mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation

28 September 2017

1 reference

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Further development and validation of empirical scoring functions for structure-based binding affinity prediction

28 September 2017

1 reference

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Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

28 September 2017

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Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

28 September 2017

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Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome

28 September 2017

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MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis.

28 September 2017

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MdmX protects p53 from Mdm2-mediated degradation

28 September 2017

1 reference

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p53 and human cancer: the first ten thousand mutations.

28 September 2017

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28 September 2017

Mdm2: the ups and downs

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The MDM2 gene amplification database

28 September 2017

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Identification of novel mdm2 binding peptides by phage display.

28 September 2017

1 reference

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Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides.

28 September 2017

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The p53 proto-oncogene can act as a suppressor of transformation

28 September 2017

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Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line

28 September 2017

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Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

28 September 2017

1 reference

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Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse

28 September 2017

1 reference

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Regulation and significance of apoptosis in the stem cells of the gastrointestinal epithelium

28 September 2017

1 reference

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Our cells get stressed too! Implications for human disease

28 September 2017

1 reference

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Inactivation of the p53 pathway in retinoblastoma.

30 May 2018

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Comparison of the NCI open database with seven large chemical structural databases.

30 May 2018

1 reference

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Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells.

30 May 2018

1 reference

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Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.

30 May 2018

1 reference

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Structure and organization of amplified DNA on double minutes containing the mdm2 oncogene

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

30 May 2018

1 reference

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Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

30 May 2018

1 reference

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Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL).

28 November 2018

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Structure-based design of potent non-peptide MDM2 inhibitors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

National Cancer Institute Drug Information System 3D database.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676449

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis

28 November 2018

1 reference

12 December 2020

Comparative study of the p53-mdm2 and p53-MDMX interfaces

1 reference

12 December 2020

Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors

1 reference

12 December 2020

Levels of HdmX Expression Dictate the Sensitivity of Normal and Transformed Cells to Nutlin-3

1 reference

12 December 2020

Antiangiogenic Activity of the MDM2 Antagonist Nutlin-3

1 reference

12 December 2020

Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia

1 reference

12 December 2020

Incidence and prognostic significance of MDM2 oncoprotein overexpression in relapsed childhood acute lymphoblastic leukemia

1 reference

12 December 2020

Mdm2 gene amplification in gastric cancer correlation with expression of Mdm2 protein and p53 alterations

1 reference

12 December 2020

Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53

1 reference

12 December 2020

10.1146/ANNUREV.PHARMTOX.48.113006.094723

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18834305%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18834305%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

2 references