GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum. (Q46174339)

http://europepmc.org/abstract/MED/15788781

20 December 2017

title

GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum (English)

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12 May 2020

6

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Stephen G Brickley

2

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Amber L Southwell

4

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12 May 2020

Henry Lester

8

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12 May 2020

author name string

Chi-Sung Chiu

1

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12 May 2020

Kimmo Jensen

3

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Sheri Mckinney

5

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Istvan Mody

7

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language of work or name

English

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publication date

1 March 2005

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http://europepmc.org/abstract/MED/15788781

20 December 2017

published in

Journal of Neuroscience

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12 May 2020

volume

25

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issue

12

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12 May 2020

page(s)

3234-3245

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Daily activity and body temperature rhythms do not change simultaneously with age in laboratory mice

12 May 2020

cites work

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12 December 2020

GABAA receptor modulation of temperature sensitive neurons in the diagonal band of Broca in vitro

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Purkinje cell degeneration, a new neurological mutation in the mouse

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GABA synchronizes clock cells within the suprachiasmatic circadian clock.

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Influence of benzodiazepines on body weight and food intake in obese and lean Zucker rats

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Slow desensitization regulates the availability of synaptic GABA(A) receptors

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Tiagabine versus phenytoin and carbamazepine as add-on therapies: effects on abilities, adjustment, and mood.

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Transgenic mice overexpressing gamma-aminobutyric acid transporter subtype I develop obesity

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Pharmacology and clinical experience with tiagabine

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Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance

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Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).

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Tiagabine (gabitril) experience in children

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GABA(A) and GABA(B) receptors in the anterior piriform cortex modulate feeding in rats

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GABA-induced current and circadian regulation of chloride in neurones of the rat suprachiasmatic nucleus

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12 December 2020

TrkB receptor signaling is required for establishment of GABAergic synapses in the cerebellum

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12 December 2020

Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex

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12 December 2020

Disease-specific human glycine receptor alpha1 subunit causes hyperekplexia phenotype and impaired glycine- and GABA(A)-receptor transmission in transgenic mice.

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12 December 2020

The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area.

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12 December 2020

GAT-1 and reversible GABA transport in Bergmann glia in slices

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12 December 2020

Number, density, and surface/cytoplasmic distribution of GABA transporters at presynaptic structures of knock-in mice carrying GABA transporter subtype 1-green fluorescent protein fusions.

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The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review

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GABA transporter-1 (GAT1)-deficient mice: differential tonic activation of GABAA versus GABAB receptors in the hippocampus.

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Newer antiepileptic drugs and cognitive issues

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Dynamic equilibrium of neurotransmitter transporters: not just for reuptake anymore

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Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior.

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12 December 2020

Comparison of the effect of the GABA uptake blockers, tiagabine and nipecotic acid, on inhibitory synaptic efficacy in hippocampal CA1 neurones

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Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality

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12 December 2020

NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization

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12 December 2020

Modulation of glutamate mobility reveals the mechanism underlying slow-rising AMPAR EPSCs and the diffusion coefficient in the synaptic cleft

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12 December 2020

Role of the GABA transporter in epilepsy.

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12 December 2020

Effects of the GABA uptake inhibitor tiagabine on inhibitory synaptic potentials in rat hippocampal slice cultures

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12 December 2020

Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor

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12 December 2020

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12 December 2020

Immunocytochemical localization of the GABA transporter in rat brain.

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12 December 2020

Gamma-aminobutyric acid uptake and the termination of inhibitory synaptic potentials in the rat hippocampal slice

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12 December 2020

Quantitative morphology and synaptology of cerebellar glomeruli in the rat

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12 December 2020

Rapid preparation of synaptosomes from mammalian brain using nontoxic isoosmotic gradient material (Percoll).

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12 December 2020

Local and diffuse synaptic actions of GABA in the hippocampus

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12 December 2020

Lack of tolerance to the anticonvulsant effects of tiagabine following chronic (21 day) treatment

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12 December 2020

Production of specific antibodies against GABA transporter subtypes (GAT1, GAT2, GAT3) and their application to immunocytochemistry

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12 December 2020

Factors contributing to the decay of the stimulus-evoked IPSC in rat hippocampal CA1 neurons.

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12 December 2020

Neuronal and glial localization of two GABA transporters (GAT1 and GAT3) in the rat cerebellum.

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12 December 2020

Postischemic inhibition of GABA reuptake by tiagabine slows neuronal death in the gerbil hippocampus

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12 December 2020

Different mechanisms regulate IPSC kinetics in early postnatal and juvenile hippocampal granule cells.

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12 December 2020

Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors

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12 December 2020

Phenotypic heterogeneity and disease course in three murine strains with mutations in genes encoding for alpha 1 and beta glycine receptor subunits

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12 December 2020

Immunoreactivity for GABA plasma membrane transporter, GAT-1, in the developing rat cerebral cortex: transient presence in the somata of neocortical and hippocampal neurons

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12 December 2020

Development of action potential-dependent and independent spontaneous GABAA receptor-mediated currents in granule cells of postnatal rat cerebellum

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12 December 2020

Cognitive and quality of life effects of differing dosages of tiagabine in epilepsy

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12 December 2020

Sex differences in the response to GABA antagonists depend on the route of drug administration.

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12 December 2020

Genetic dissection of functional contributions of specific potassium channel subunits in habituation of an escape circuit in Drosophila.

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12 December 2020

Tiagabine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the management of epilepsy

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12 December 2020

Effects of tiagabine monotherapy on abilities, adjustment, and mood.

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12 December 2020

Spillover-mediated transmission at inhibitory synapses promoted by high affinity alpha6 subunit GABA(A) receptors and glomerular geometry.

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12 December 2020

Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination.

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12 December 2020

Pharmacological characterization of nicotinic receptor-stimulated GABA release from mouse brain synaptosomes.

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12 December 2020

Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.

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12 December 2020

10.1523/JNEUROSCI.3364-04.2005

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725086&resulttype=core&format=json

12 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725086&resulttype=core&format=json

12 May 2020

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